Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]
, 2011 NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
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Quantitative phosphoproteomics of cytotoxic T cells to reveal Protein Kinase D 2 regulated networks [PDF]
, 2014 The focus of the present study was to characterize the phosphoproteome of cytotoxic T cells and to explore the role of the serine threonine kinase PKD2 (Protein Kinase D2) in the phosphorylation networks of this key lymphocyte population.
Goebel, Juergen +3 more
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Case report: A novel frameshift mutation in BRSK2 causes autism in a 16-year old Chinese boy
Frontiers in Psychiatry, 2023 Serine/threonine protein kinases are involved in axon formation and neuronal polarization and have recently been implicated in autism spectrum disorder (ASD) and neurodevelopmental disorders (NDD).
Yu Hu +18 more
doaj +1 more source
Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]
, 2013 ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep +29 more
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Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization
Nature Communications, 2021 Bone morphogenetic protein (BMP) receptors are single pass transmembrane serine/threonine kinases that form tetrameric complexes comprised of two type I and two type II BMP receptors.
Christopher Agnew +10 more
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Identifying and characterizing a novel protein kinase STK35L1 and deciphering its orthologs and close-homologs in vertebrates. [PDF]
, 2009 The human kinome containing 478 eukaryotic protein kinases has over 100 uncharacterized kinases with unknown substrates and biological functions. The Ser/Thr kinase 35 (STK35, Clik1) is a member of the NKF 4 (New Kinase Family 4) in the kinome with ...
Pankaj Goyal +11 more
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Detection of HBV C Protein Phosphorylation in the Cell
Bio-Protocol, 2015 Among the seven serines and one threonine in the carboxyl-terminus of HBV C protein, all but one (serine 183) appear in the context of RxxS/T consensus phosphoacceptor motifs and also overlap with other consensus motifs, such as S/TP, RS, SPRRR, RRRS/T ...
Jaesung Jung, Kyongmin Kim
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Analysis of the structure and function of protein phosphatase 2A [PDF]
, 2004 One of the hallmarks of a living organism is the ability to respond to intra- or extracellular changes. These responses involve panoply of enzymes mediating signals through the cell and regulating distinct cellular functions.
Schmidt, Karsten
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Genome-wide survey of putative Serine/Threonine protein kinases in cyanobacteria
BMC Genomics, 2007 Background Serine/threonine kinases (STKs) have been found in an increasing number of prokaryotes, showing important roles in signal transduction that supplement the well known role of two-component system.
Guan Xiangyu +5 more
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Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]
, 2014 The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-a1 (AMP-activated protein kinase-a1 ...
Leslie, Nicholas R. +6 more
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