Results 21 to 30 of about 209,848 (307)
Frontiers in Microbiology, 2014 Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Lei eShi +7 more
doaj +1 more source
STRUCTURE, ACTIVATION AND BIOLOGICAL EFFECTS OF AKT OR PROTEIN KINASE B [PDF]
Romanian Journal of Medical Practice, 2019 AKT or protein kinase B is a serine / threonine kinase that plays a crucial role in cell proliferation, survival, growth, and glucose metabolism. So far, there have been discovered 3 isoforms of AKT, the most widespread in the tissues is AKT1.
Daniela Miricescu +8 more
doaj +1 more source
Phosphorylation is required for the pathogen defense function of the Arabidopsis PEN3 ABC transporter. [PDF]
, 2017 The Arabidopsis PEN3 ABC transporter accumulates at sites of pathogen detection, where it is involved in defense against a number of pathogens. Perception of PAMPs by pattern recognition receptors initiates recruitment of PEN3 and also leads to PEN3 ...
Somerville, Shauna, Underwood, William
core +1 more source
Frontiers in Microbiology, 2021 The Planctomycetes bacteria have unique cell architectures with heavily invaginated membranes as confirmed by three-dimensional models reconstructed from FIB-SEM images of Tuwongella immobilis and Gemmata obscuriglobus.
Christian Seeger +5 more
doaj +1 more source
KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]
, 2015 The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo +6 more
core +1 more source
Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Nature Communications, 2022 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation.
Hailin Tu +4 more
doaj +1 more source
The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]
, 2011 Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P. +2 more
core +3 more sources
Impact of Serine/Threonine Protein Kinases on the Regulation of Sporulation in Bacillus subtilis.
Frontiers in Microbiology, 2016 Bacteria possess many kinases that catalyze phosphorylation of proteins on diverse amino acids including arginine, cysteine, histidine, aspartate, serine, threonine and tyrosine.
Frédérique ePompeo +2 more
doaj +1 more source
Biology, 2021 Dengue virus infection is a global health problem for which there have been challenges to obtaining a cure. Current vaccines and anti-viral drugs can only be narrowly applied in ongoing clinical trials.
Lamya Alomair +3 more
doaj +1 more source
Discovery of a Selective NEK6 Kinase Inhibitor by Virtual Screening
Proceedings, 2019 NIMA-related kinases (Neks) are a conserved serine/threonine protein kinase family related tocell cycle progression and cell division [...]
Benedetta Righino +8 more
doaj +1 more source