Results 31 to 40 of about 209,848 (307)

Correlated mutation analysis on the catalytic domains of serine/threonine protein kinases. [PDF]

PLoS ONE, 2009
BACKGROUND:Protein kinases (PKs) have emerged as the largest family of signaling proteins in eukaryotic cells and are involved in every aspect of cellular regulation.
Feng Xu, Pan Du, Hongbo Shen, Hairong Hu, Qi Wu, Jun Xie, Long Yu   +6 more
doaj   +1 more source

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations

Frontiers in Bioscience-Landmark, 2022
Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have ...
Khoa Nguyen, Hassan Yousefi, Thomas Cheng, Justin Magrath, Alifiani B. Hartono, Madlin Alzoubi, Katherine Hebert, Courtney K. Brock, Maryl K. Wright, Charles Ethan Byrne, Andrew Rivera, Sam C. Okpechi, Margarite Delores Matossian, Henri Wathieu, Steven Elliott, Mark J. Mondrinos, Sean B. Lee, Bridgette M. Collins-Burow, Suresh K. Alahari, David H. Drewry, Matthew E. Burow   +20 more
doaj   +1 more source

Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]

, 1998
The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core   +2 more sources

Phosphoproteomics analysis of a clinical Mycobacterium tuberculosis Beijing isolate: Expanding the mycobacterial phosphoproteome catalogue

Frontiers in Microbiology, 2015
Reversible protein phosphorylation, regulated by protein kinases and phosphatases, mediates a switch between protein activity and cellular pathways that contribute to a large number of cellular processes.
Suereta eFortuin, Gisele eTomazella, Naga eNagayaryan, Samantha eSampson, Nicolaas eGey van Pittius, Nelson Da Cruz Soares, Harald eWiker, Gustavo eDe Souza, Robin Mark Warren   +8 more
doaj   +1 more source

Computational identification of signalling pathways in Plasmodium falciparum [PDF]

, 2011
Malaria is one of the world’s most common and serious diseases causing death of about 3 million people each year. Its most severe occurrence is caused by the protozoan Plasmodium falciparum.
Adebiyi, E. F., Brors, B., Eils, R., Isewon, Itunuoluwa, Oyelade, O. J.   +4 more
core   +2 more sources

Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling [PDF]

, 2011
Some apicomplexan parasites have evolved distinct protein kinase families to modulate host cell structure and function. Toxoplasma gondii rhoptry protein kinases and pseudokinases are involved in virulence and modulation of host cell signalling.
Abdi, Agarwal, Allen, Anamika, Behnke, Billker, Billker, Bishop, Blethrow, Bracchi-Ricard, Bradley, Brian M. Cooke, Butcher, Carruthers, Carvalho, Christian Doerig, Cooke, Cooke, Coppi, Dalpke, Daniel C. Lim, Dar, Doerig, Doerig, Doerig, Dorin, Dorin, Dorin, Droucheau, El Hajj, Fennell, Fentress, Gilbert, Green, Gueirard, Halbert, Hanks, Huse, Hutti, Ishino, Jensen, Jeroen P.J. Saeij, Kafsack, Kannan, Kato, Khaminets, Khan, Khan, Khan, Kieschnick, Kun, Kuo, Labesse, Ling, Lodoen, Lourido, Luder, Manning, Martens, Melzer, Nagamune, Nunes, Nunes, Ojo, Ong, Parsons, Peixoto, Pernas, Qiu, Reese, Reese, Reese, Reininger, Reininger, Reininger, Rosenberg, Rosowski, Saeij, Saeij, Scheibel, Schneider, Shiels, Sicard, Singh, Singh, Solyakov, Sopko, Steinfeldt, Sugi, Suss-Toby, Taylor, Taylor, Tewari, Vaid, van de Sand, Ward, Ward, Wernimont, Wernimont, Xu, Yamamoto, Yasukawa, Zeqiraj, Zeqiraj, Zhao, Zhao   +105 more
core   +2 more sources

Mapping the phosphoproteome of influenza A and B viruses by mass spectrometry [PDF]

, 2012
Protein phosphorylation is a common post-translational modification in eukaryotic cells and has a wide range of functional effects. Here, we used mass spectrometry to search for phosphorylated residues in all the proteins of influenza A and B viruses ...
Denham, Eleanor M., Fodor, Ervin, Hester, Svenja S., Hutchinson, Edward C., Ridlova, Gabriela, Thomas, Benjamin, Trudgian, David C., Turrell, Lauren, York, Ashley   +8 more
core   +3 more sources

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Nature Communications, 2021
Bone morphogenetic protein (BMP) receptors are single pass transmembrane serine/threonine kinases that form tetrameric complexes comprised of two type I and two type II BMP receptors.
Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura   +10 more
doaj   +1 more source

New insights into the mechanisms of phytochrome-cryptochrome coaction. [PDF]

, 2018
Contents Summary 547 I. Introduction 547 II. Phytochromes mediate light-induced transcription of BICs to inactivate cryptochromes 548 III. PPKs phosphorylate light-signaling proteins and histones to affect plant development 548 IV.
Ahmad, Bourbousse, Bourbousse, Casas-Mollano, Cashmore, Devlin, Guo, Hoecker, Huang, Hughes, Huq, Ichikawa, Jang, Leivar, Lian, Liu, Liu, Liu, Lu, Ma, Martinez-Garcia, Mas, Mohr, Ni, Ni, Ni, Nusinow, Pedmale, Quail, Rosenfeldt, Saijo, Sang, Sellaro, Shalitin, Sheerin, Su, Su, Tessadori, Tessadori, Wang, Wang, Wang, Wang, Wang, Weidler, Yang, Zheng, Zuo   +47 more
core   +1 more source

Mutations of the BRAF gene in human cancer [PDF]

, 2002
Cancers arise owing to the accumulation of mutations in critical genes that alter normal programmes of cell proliferation, differentiation and death. As the first stage of a systematic genome-wide screen for these genes, we have prioritized for analysis ...
Bignell, G.R., Bigner, D.D., Bottomley, W., Chenevix-Trench, G., Clegg, S., Cooper, C., Cossu, A., Cox, C., Darrow, T.L., Davies, H., Davis, N., Dicks, E., Edkins, S., Ewing, R., Flanagan, A., Floyd, Y., Futreal, P.A., Garnett, M.J., Gray, K., Gusterson, B.A., Hall, S., Hargrave, D., Hawes, R., Ho, J.W.C., Hooper, S., Hughes, J., Jayatilake, H., Kosmidou, V., Leung, S.Y., Maitland, N., Marais, R., Marshall, C.J., Menzies, A., Mould, C., Nicholson, A., Palmieri, G., Parker, A., Paterson, H., Pritchard-Jones, K., Riggins, G.J., Seigler, H.F., Shipley, J., Stephens, P., Stevens, C., Stratton, M.R., Teague, J., Watt, S., Weber, B.L., Wilson, R., Woffendin, H., Wooster, R., Yuen, S.T.   +51 more
core   +1 more source