Results 31 to 40 of about 138,869 (211)

Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Nature Communications, 2021
Bone morphogenetic protein (BMP) receptors are single pass transmembrane serine/threonine kinases that form tetrameric complexes comprised of two type I and two type II BMP receptors.
Christopher Agnew, Pelin Ayaz, Risa Kashima, Hanna S. Loving, Prajakta Ghatpande, Jennifer E. Kung, Eric S. Underbakke, Yibing Shan, David E. Shaw, Akiko Hata, Natalia Jura   +10 more
doaj   +1 more source

Case report: A novel frameshift mutation in BRSK2 causes autism in a 16-year old Chinese boy

Frontiers in Psychiatry, 2023
Serine/threonine protein kinases are involved in axon formation and neuronal polarization and have recently been implicated in autism spectrum disorder (ASD) and neurodevelopmental disorders (NDD).
Yu Hu, Yu Hu, Miao Li, Miao Li, Yanmei Shen, Tianyun Wang, Tianyun Wang, Tianyun Wang, Tianyun Wang, Qiwei Liu, Qiwei Liu, Qiwei Liu, Zhonghua Lu, Zhonghua Lu, Hong Wang, Hong Wang, Xuerong Luo, Lixin Yang, Lixin Yang   +18 more
doaj   +1 more source

Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases

BMC Genomics, 2010
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A
Nyporko Alexey, Matusov Vadym G, Yemets Alla I, Nadezhdina Elena S, Karpov Pavel A, Shashina Nadezhda, Blume Yaroslav B   +6 more
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Detection of HBV C Protein Phosphorylation in the Cell

Bio-Protocol, 2015
Among the seven serines and one threonine in the carboxyl-terminus of HBV C protein, all but one (serine 183) appear in the context of RxxS/T consensus phosphoacceptor motifs and also overlap with other consensus motifs, such as S/TP, RS, SPRRR, RRRS/T ...
Jaesung Jung, Kyongmin Kim
doaj   +1 more source

Genome-wide survey of putative Serine/Threonine protein kinases in cyanobacteria

BMC Genomics, 2007
Background Serine/threonine kinases (STKs) have been found in an increasing number of prokaryotes, showing important roles in signal transduction that supplement the well known role of two-component system.
Guan Xiangyu, Zhao Fangqing, Zhang Xiaowen, Yang Yu, Liang Chengwei, Qin Song   +5 more
doaj   +1 more source

Structural Insights into Protein Regulation by Phosphorylation and Substrate Recognition of Protein Kinases/Phosphatases

Life, 2021
Protein phosphorylation is one of the most widely observed and important post-translational modification (PTM) processes. Protein phosphorylation is regulated by protein kinases, each of which covalently attaches a phosphate group to an amino acid side ...
Seung-Hyeon Seok
doaj   +1 more source

Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity

eLife, 2020
PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes.
Lukas M Langer, Yair Gat, Fabien Bonneau, Elena Conti   +3 more
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Phosphorylation and regulation of group II metabotropic glutamate receptors (mGlu2/3) in neurons

Frontiers in Cell and Developmental Biology, 2022
Group II metabotropic glutamate (mGlu) receptors (mGlu2/3) are Gαi/o-coupled receptors and are primarily located on presynaptic axonal terminals in the central nervous system.
Li-Min Mao, Nirav Mathur, Tayyibah Mahmood, Sri Rajan, Xiang-Ping Chu, John Q. Wang, John Q. Wang   +6 more
doaj   +1 more source

The juxtamembrane domain of StkP is phosphorylated and influences cell division in Streptococcus pneumoniae

mBio
Eukaryotic-like membrane Ser/Thr protein kinases play a pivotal role in different aspects of bacterial physiology. In contrast to the diversity of their extracellular domains, their cytoplasmic catalytic domains are highly conserved.
Mélisse Hamidi, Sathya Narayanan Nagarajan, Vaishnavi Ravikumar, Virginie Gueguen-Chaignon, Cédric Laguri, Céline Freton, Ivan Mijakovic, Jean-Pierre Simorre, Stéphanie Ravaud, Christophe Grangeasse   +9 more
doaj   +1 more source

Structure-based virtual screening for novel p38 MAPK inhibitors and a biological evaluation

Acta Materia Medica, 2023
Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease processes, while inhibition of p38α has been shown to have potential therapeutic
Qinwen Zheng, Yumeng Zhu, Aoxue Wang, Panpan Yang, Xin Wang, Wen Shuai, Liang Ouyang, Guan Wang   +7 more
doaj   +1 more source