Results 31 to 40 of about 142,215 (332)
Frontiers in Microbiology, 2014 Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Lei eShi +7 more
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Bacterial Serine/Threonine Protein Kinases in Host-Pathogen Interactions [PDF]
Journal of Biological Chemistry, 2014 In bacterial pathogenesis, monitoring and adapting to the dynamically changing environment in the host and an ability to disrupt host immune responses are critical. The virulence determinants of pathogenic bacteria include the sensor/signaling proteins of the serine/threonine protein kinase (STPK) family that have a dual role of sensing the environment
Canova, Marc, Molle, Virginie
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Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation
Nature Communications, 2022 Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation.
Hailin Tu +4 more
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Biology, 2021 Dengue virus infection is a global health problem for which there have been challenges to obtaining a cure. Current vaccines and anti-viral drugs can only be narrowly applied in ongoing clinical trials.
Lamya Alomair +3 more
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Resolving the binding-kinase discrepancy in bacterial chemotaxis: A nonequilibrium allosteric model and the role of energy dissipation [PDF]
Proc. Natl. Acad. Sci. U.S.A. 120, e2303115120 (2023), 2023 The Escherichia coli chemotaxis signaling pathway has served as a model system for studying the adaptive sensing of environmental signals by large protein complexes. The chemoreceptors control the kinase activity of CheA in response to the extracellular ligand concentration and adapt across a wide concentration range by undergoing methylation and ...
arxiv +1 more source
Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations. [PDF]
Journal of Biological Chemistry, 1991 Mitogen-activated protein kinase (p42mapk) becomes transiently activated after treatment of serum-starved murine Swiss 3T3 cells or EL4 thymocytes with a diversity of mitogens. Similarly, a meiosis-activated protein kinase (p44mpk) becomes stimulated during maturation of sea star oocytes induced by 1-methyladenine.
A J Rossomando +5 more
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Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations
Frontiers in Bioscience-Landmark, 2022 Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have ...
Khoa Nguyen +20 more
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Discovery of a Selective NEK6 Kinase Inhibitor by Virtual Screening
Proceedings, 2019 NIMA-related kinases (Neks) are a conserved serine/threonine protein kinase family related tocell cycle progression and cell division [...]
Benedetta Righino +8 more
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The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron [PDF]
Physiological Reports, 2019 The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in the aldosterone-sensitive distal nephron (ASDN) and stimulating a complex transcriptional, translational, and cellular program. Because the complexity of the aldosterone response is still not fully
Spirli, Alessia +8 more
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Frontiers in Microbiology, 2015 Reversible protein phosphorylation, regulated by protein kinases and phosphatases, mediates a switch between protein activity and cellular pathways that contribute to a large number of cellular processes.
Suereta eFortuin +8 more
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