Results 41 to 50 of about 261,891 (384)

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]

, 2014
The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser(487) in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-α1 (AMP-activated protein kinase-α1),
Chen, Cross, D. Grahame Hardie, Dagon, Dale, Davidson, Davies, Davies, Decensi, Evans, Faubert, Fiona A. Ross, Fogarty, Frame, Goransson, Gowans, Graeme J. Gowans, Hardie, Hawley, Hawley, Hawley, Hawley, Hawley, Hawley, Hirai, Horman, Hurley, Hurley, Ji, Lee, Lizcano, Mankouri, Nicholas R. Leslie, Ning, Obata, Obenauer, Priyanka Tibarewal, Roach, Sanchez-Cespedes, Sanders, Scott, Shaw, Simon A. Hawley, Street, Suzuki, Towler, Wingo, Woods, Woods, Woods, Woods, Xiao, Xiao, Yuan   +53 more
core   +4 more sources

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
A Kortholt, A Kortholt, AA Noegel, Adrian John Harwood, BK Gilsbach, C Blanc, Christoph S. Clemen, CR Thompson, DE Levy, H Kiu, H Kuwayama, H Towbin, J Faix, J Langenick, J Na, Jeffrey G. Williams, Jianbo Na, JM Goldberg, K Adler, KL Williams, L Gebbie, Linh Hai Vu, Ludwig Eichinger, M Brink, M Fukuzawa, M Gamper, MR Lee, NS Lee, P Farbrother, P Gatsios, R Kang, RH Insall, T Araki, T Araki, T Araki, T Araki, Tsuyoshi Araki, UK Laemmli   +37 more
core   +9 more sources

LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]

, 2010
The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Aifantis, Aifantis, Alessi, Azzam, Bonaccorsi, Borowski, Boudeau, Bozulic, Cantrell, Cantrell, Cantrell, Chang, Choi, Ciofani, Ciofani, de Pooter, Frauwirth, Goldstein, Hardie, Hardie, Hayday, Hemminki, Hezel, Hinton, Hurov, Hurov, Ji, Jones, Juntilla, Kelly, Koo, Laky, Lee, Liang, Lizcano, Mao, Mayer, Michie, Mirouse, Partanen, Rodewald, Sakamoto, Sanchez-Cespedes, Schmitt, Shaw, Shaw, Smith-Garvin, Takahama, Takahama, Tamas, Ylikorkala   +50 more
core   +5 more sources

Biochemical characterization of a family of serine/threonine protein kinases regulated by tyrosine and serine/threonine phosphorylations. [PDF]

Journal of Biological Chemistry, 1991
Mitogen-activated protein kinase (p42mapk) becomes transiently activated after treatment of serum-starved murine Swiss 3T3 cells or EL4 thymocytes with a diversity of mitogens. Similarly, a meiosis-activated protein kinase (p44mpk) becomes stimulated during maturation of sea star oocytes induced by 1-methyladenine.
A J Rossomando, Thomas W. Sturgill, Michael J. Weber, S L Pelech, J S Sanghera, L A Marsden   +5 more
openaire   +2 more sources

Tyrosine phosphorylation regulates RIPK1 activity to limit cell death and inflammation

Nature Communications, 2022
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is an important regulator of cell death pathways during embryogenesis and in infection/inflammation.
Hailin Tu, Weihang Xiong, Jie Zhang, Xueqiang Zhao, Xin Lin   +4 more
doaj   +1 more source

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]

, 2015
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo, Fumagallo, Felipe, Gillespie, David A., Gong, Eun Yeung, Morrice, Nicholas, Piscitello, Desiree, Smits, Veronique A.J.   +6 more
core   +1 more source

In Silico Prediction of the Phosphorylation of NS3 as an Essential Mechanism for Dengue Virus Replication and the Antiviral Activity of Quercetin

Biology, 2021
Dengue virus infection is a global health problem for which there have been challenges to obtaining a cure. Current vaccines and anti-viral drugs can only be narrowly applied in ongoing clinical trials.
Lamya Alomair, Fahad Almsned, Aman Ullah, Mohsin S. Jafri   +3 more
doaj   +1 more source

The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]

, 2011
Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P., Traynor, Ryan, Vogt, Janis   +2 more
core   +3 more sources

Discovery of a Selective NEK6 Kinase Inhibitor by Virtual Screening

Proceedings, 2019
NIMA-related kinases (Neks) are a conserved serine/threonine protein kinase family related tocell cycle progression and cell division [...]
Benedetta Righino, Marta De Donato, Flavia Filippetti, Alessandra Battaglia, Marco Petrillo, Davide Pirolli, Giovanni Scambia, Daniela Gallo, Maria Cristina De Rosa   +8 more
doaj   +1 more source

Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations

Frontiers in Bioscience-Landmark, 2022
Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have ...
Khoa Nguyen, Hassan Yousefi, Thomas Cheng, Justin Magrath, Alifiani B. Hartono, Madlin Alzoubi, Katherine Hebert, Courtney K. Brock, Maryl K. Wright, Charles Ethan Byrne, Andrew Rivera, Sam C. Okpechi, Margarite Delores Matossian, Henri Wathieu, Steven Elliott, Mark J. Mondrinos, Sean B. Lee, Bridgette M. Collins-Burow, Suresh K. Alahari, David H. Drewry, Matthew E. Burow   +20 more
doaj   +1 more source