Results 51 to 60 of about 133,461 (307)
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
CPG16, a Novel Protein Serine/Threonine Kinase Downstream of cAMP-dependent Protein Kinase [PDF]
Journal of Biological Chemistry, 1999 Gene expression is necessary for the formation and consolidation of long term memory in both invertebrates and vertebrates. Here, we describe the expression and characterization of candidate plasticity gene 16 (cpg16), a protein serine/threonine kinase that was previously isolated from rat hippocampus as a plasticity-related gene. CPG16, when expressed
Yoav Citri +5 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
Subcellular partitioning of protein kinase activity revealed by functional kinome profiling
Scientific Reports, 2022 Protein kinases and their substrates form signaling networks partitioned across subcellular compartments to facilitate critical biological processes. While the subcellular roles of many individual kinases have been elucidated, a comprehensive assessment ...
Lauren Wegman-Points +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Diversity in Serine/Threonine Protein Kinase-4 Deficiency and Review of the Literature
The Journal of Allergy and Clinical Immunology: In Practice, 2021 Serine/threonine kinase-4 (STK4) deficiency is an autosomal recessive combined immunodeficiency.We aimed to define characteristic clinical and laboratory features to aid the differential diagnosis and determine the most suitable therapy.In addition to nine STK4 deficiency patients, we reviewed 15 patients from the medical literature.
Deniz Cagdas +14 more
openaire +5 more sources
BMC Cancer, 2020 Background Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CCA recurrence is not well ...
Sureerat Padthaisong +7 more
doaj +1 more source
Molecular Oncology, EarlyView.In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková +14 more
wiley +1 more source
Biology and pharmacological inhibition of homeodomain-interacting protein kinases
Frontiers in Chemical BiologyHomeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of ...
Adam Štefek +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi +12 more
wiley +1 more source