Results 101 to 110 of about 13,913,476 (302)

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

DPANet: Dual-Encoder Protein Attention Network for Secondary Structure Prediction

IEEE Access
Protein secondary structure prediction is essential for understanding protein function and informing downstream structural modeling. We introduce DPANet, a dual-encoder protein attention network that integrates primary amino acid sequences and ...
Sina Abbaskhani, Masoud Kargar, Ali Bayani, Alireza Assadzadeh   +3 more
doaj   +1 more source

Les mécanismes de repliement des protéines solubles [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2000
Mechanisms of folding of soluble proteins. The function of a protein is carried out by its three-dimensional structure. The rules for translation of the information encoded by DNAinto an amino acid sequence are well known.
Brasseur B., Benhabilès N., Thomas A.
doaj  

Integration of Multi-Feature Fusion and PLS-DA in Protein Secondary Structure Prediction

MATEC Web of Conferences, 2016
Protein structure prediction has become one of the central problems in the field of modern computational biology. Protein secondary structure prediction is the basis of the spatial structure prediction of proteins.
Huang Guangzao, Tang Meishuang, Guan Jinting, Zhou Sun, Zhu Wenbing, Ji Guoli   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Electrostatic interactions and secondary structures in proteins

Biophysical Journal, 1980
In an attempt to understand the occurrences of secondary forms in proteins, we have calculated approximate free energies for a large set of regular secondary regions and have compared several methods for choosing a single molecular conformation. Approximate conformational free energies have been obtained by directly calculating electrostatic energies ...
Jernigan, R.L., Miyazawa, S., Szu, S.C.
openaire   +2 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Calibration and standardisation of synchrotron radiation circular dichroism and conventional circular dichroism spectrophotometers [PDF]

, 2003
Synchrotron radiation circular dichroism (SRCD) is an emerging technique in structural biology with particular value in protein secondary structure analyses since it permits the collection of data down to much lower wavelengths than conventional ...
Wien, Frank, Wallace, Bonnie Ann, Rodger, Alison, Lees, Jonathan G., Miles, Andrew J.   +4 more
core  

PALSSE: A program to delineate linear secondary structural elements from protein structures

BMC Bioinformatics, 2005
Background The majority of residues in protein structures are involved in the formation of α-helices and β-strands. These distinctive secondary structure patterns can be used to represent a protein for visual inspection and in vector-based protein ...
Grishin Nick V, Krishna S Sri, Majumdar Indraneel   +2 more
doaj   +1 more source