Results 81 to 90 of about 1,631,863 (295)

Prediction of chaperonin GroE substrates using small structural patterns of proteins

FEBS Open Bio, 2023
Molecular chaperones are indispensable proteins that assist the folding of aggregation‐prone proteins into their functional native states, thereby maintaining organized cellular systems.
Shintaro Minami, Tatsuya Niwa, Eri Uemura, Ryotaro Koike, Hideki Taguchi, Motonori Ota   +5 more
doaj   +1 more source

Protein Secondary Structure Prediction

, 2008
{"references": ["Cuff, J. A. and Barton, G.J. \"Evaluation and improvement of multiple\nsequence methods for protein secondary structure prediction. Proteins,\n34, 1999, pp. 508-519.", "Cuff, J.A. and Barton G.J. \"Application of multiple sequence alignment\nprofiles to improve protein secondary structure prediction\" Proteins, 40,\n2000, pp. 502-511.",
Manpreet Singh, Sandhu, Parvinder Singh, Kaur, Reet Kamal   +2 more
openaire   +1 more source

Secondary structure of globular proteins at the early and the final stages in protein folding [PDF]

, 1993
The ellipticities for an early transient intermediate in refolding observed by kinetic circular dichroism measurements at 220–225 nm for 14 different proteins are summarized, and the ellipticity values are compared with those for the final native ...
FINKELSTEIN Alexei V, KUWAJIMA Kunihiro, PTITSYN Oleg B, SEMISOTNOV Gennady V, SUGAI Shintaro, 邦博 桑島   +5 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Deep learning for protein secondary structure prediction: Pre and post-AlphaFold

Computational and Structural Biotechnology Journal, 2022
This paper aims to provide a comprehensive review of the trends and challenges of deep neural networks for protein secondary structure prediction (PSSP). In recent years, deep neural networks have become the primary method for protein secondary structure
Dewi Pramudi Ismi, Reza Pulungan, Afiahayati   +2 more
doaj   +1 more source

Improving protein fold recognition using the amalgamation of evolutionary-based and structural-based information [PDF]

, 2014
Deciphering three dimensional structure of a protein sequence is a challenging task in biological science. Protein fold recognition and protein secondary structure prediction are transitional steps in identifying the three dimensional structure of a ...
Dehzangi, A., Lyons, J., Paliwal, K.K., Sharma, Alokanand   +3 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Complete Genome Characterization of the 2017 Dengue Outbreak in Xishuangbanna, a Border City of China, Burma and Laos

Frontiers in Cellular and Infection Microbiology, 2018
A dengue outbreak abruptly occurred at the border of China, Myanmar, and Laos in June 2017. By November 3rd 2017, 1184 infected individuals were confirmed as NS1-positivein Xishuangbanna, a city located at the border.
Songjiao Wen, Songjiao Wen, Songjiao Wen, Dehong Ma, Yao Lin, Yao Lin, Yao Lin, Lihua Li, Shan Hong, Shan Hong, Shan Hong, Xiaoman Li, Xiaodan Wang, Xiaodan Wang, Xiaodan Wang, Juemin Xi, Juemin Xi, Juemin Xi, Lijuan Qiu, Yue Pan, Yue Pan, Yue Pan, Junying Chen, Junying Chen, Junying Chen, Xiyun Shan, Qiangming Sun, Qiangming Sun, Qiangming Sun   +28 more
doaj   +1 more source

The development of biomolecular Raman optical activity spectroscopy [PDF]

, 2015
Following its first observation over 40 years ago, Raman optical activity (ROA), which may be measured as a small difference in the intensity of vibrational Raman scattering from chiral molecules in right- and left-circularly polarized incident light or,
Barron, Laurence D.
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source