Results 231 to 240 of about 1,631,952 (291)

A Single‐Metal‐Doped Nanoplatform for Ferroptosis‐Driven cGAS‐STING Pathway Activation in Hepatocellular Carcinoma Immunotherapy

Advanced Functional Materials, EarlyView.
The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang, Shuang Feng, Jie Luo, Kaige Xu, Junfeng Guo, Xingyue Zhang, Mengxue Yuan, Qiang Luo, Yu Huang, Chaoqiang Fan, Kibret Mequanint, Donghui Zhu, Malcolm Xing, Shiming Yang   +13 more
wiley   +1 more source

Exploring the protein universe with distant similarity detection methods. [PDF]

Protein Sci
Sahakyan H, Mutz P, Tobiasson V, Koonin EV.   +3 more
europepmc   +1 more source

Fully Bio‐Based Gelatin Organohydrogels via Enzymatic Crosslinking for Sustainable Soft Strain and Temperature Sensing

Advanced Functional Materials, EarlyView.
Enzymatically crosslinked gelatin‐based organohydrogels, fabricated through a fully bio‐based and scalable process, exhibit exceptional strain and temperature sensing capabilities with minimal interference from environmental humidity. These transparent, stretchable, and ionically conductive materials operate without synthetic fillers or dopants.
Pietro Tordi, Adrián Tamayo, Yeonsu Jeong, Bin Han, Tamer Al Kayal, Aida Cavallo, Massimo Bonini, Paolo Samorì   +7 more
wiley   +1 more source

Confocal Raman microspectroscopy imaging reveals structural protein reorganization in human intracranial aneurysm tissue. [PDF]

Sci Rep
Gollwitzer M, Schäffl D, Angerer C, Leimhofer C, Weis S, Mazanec V, Gmeiner M, Gruber A, Hild S.   +8 more
europepmc   +1 more source

The Anisotropic Adsorption of De Novo Allosteric Two‐Component Protein Fibers on Mica Surfaces

Advanced Functional Materials, EarlyView.
In this study, the interfacial behavior of de novo designed proteins that self‐assemble into tubular architectures with distinct morphologies — small (S), large (L), and helical (H) fibers — at the muscovite mica‐water interface is explored using in situ AFM. Abstract Protein adsorption at solid–liquid interfaces underlies many biomedical and materials
Chenyang Shi, Hao Shen, Yuna Bae, Jaeyoung Heo, Shuai Zhang, Lehan Yao, David Baker, James J De Yoreo   +7 more
wiley   +1 more source

Rational design and in silico characterization of a multiepitope mRNA vaccine candidate against human metapneumovirus (hMPV) using reverse vaccinology and immunoinformatics approaches. [PDF]

Sci Rep
Izhari MA, Gosady ARA, Alghamdi F, Alghamdi WA, Hadadi MAA, Almontasheri AHA, Dardari DMM, Salem AA, Alotaibi FE.   +8 more
europepmc   +1 more source

Backbone resonance assignment of the pentraxin domain of the neuronal pentraxin receptor (NPTXR). [PDF]

Biomol NMR Assign
Pozhidaeva AK, Li Y, Pustovalova Y, Hoch JC, Martinelli DC, Simon B, Hao B.   +6 more
europepmc   +1 more source

Combined experimental and in silico elucidation of KP27 endolysin reveals a phage derived antibacterial with pH and thermal robustness. [PDF]

Sci Rep
Zare Z, Imani M, Aghazadeh S.
europepmc   +1 more source

Mechanism of ultrasonic treatment affecting the conformation and properties of oat-whey dual-protein gel. [PDF]

Ultrason Sonochem
Liu L, Li S, Wang S, Che J, Qin P, Wang Z, Huang Y, Shi Y, Li Y, Wang Q.   +9 more
europepmc   +1 more source

Effect of Prolonged Frozen Storage on the In Vitro Digestion of Minced Pork: Insights from Protein Structural Changes. [PDF]

Foods
Zhu Y, Chen S, Ma Y, Fu C, Huang D.
europepmc   +1 more source