Results 41 to 50 of about 319,877 (305)

Prediction of Protein Tertiary Structures Using MUFOLD [PDF]

, 2011
There have been steady improvements in protein structure prediction during the past two decades. However, current methods are still far from consistently predicting structural models accurately with computing power accessible to common users. To address this challenge, we developed MUFOLD, a hybrid method of using whole and partial template information
Jingfen, Zhang, Zhiquan, He, Qingguo, Wang, Bogdan, Barz, Ioan, Kosztin, Yi, Shang, Dong, Xu   +6 more
openaire   +2 more sources

An insight into structural plasticity and conformational transitions of transcriptional co-activator Sus1.

PLoS ONE, 2020
RNA biogenesis and mRNA transport are an intricate process for every eukaryotic cell. SAGA, a transcriptional coactivator and TREX-2 are the two major complexes participate in this process.
Akhilendra Pratap Bharati, Mohd Kashif, Sumit Kumar Chaturvedi, Rizwan Hasan Khan, Abrar Ahmad   +4 more
doaj   +1 more source

Multiple co-evolutionary networks are supported by the common tertiary scaffold of the LacI/GalR proteins. [PDF]

PLoS ONE, 2013
Protein families might evolve paralogous functions on their common tertiary scaffold in two ways. First, the locations of functionally-important sites might be "hard-wired" into the structure, with novel functions evolved by altering the amino acid (e.g.
Daniel J Parente, Liskin Swint-Kruse
doaj   +1 more source

Does a Simple Lattice Protein Exhibit Self-Organized Criticality? [PDF]

, 2015
There are many unanswered questions when it comes to protein folding. These questions are interesting because the tertiary structure of proteins determines its functionality in living organisms.
Bajracharya, Arun, Gibbon, Dana M., Runyon, Alissa A.   +2 more
core   +1 more source

Prognostic Impact of Treatment Modalities, Including Targeted Compartmental Radio‐Immunotherapy, in a Cohort of Neuroblastoma Patients With CNS Metastases at Relapse

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neuroblastoma (NB) with central nervous system (CNS) metastases is rare at diagnosis, but occurs more often during relapse/progression. Patients with CNS metastases face a dismal prognosis, with no standardized curative treatment available.
Vicente Santa‐Maria Lopez, Anna Felip‐Badia, Marina Caballero‐Bellon, Nazaret Sanchez‐Sierra, Alicia Castañeda, Moira Garraus, Maite Gorostegui, Margarida Simão‐Rafael, Juan Pablo Muñoz, Marta Perez‐Somarriba, Salvador Mañe, Mariana Cecilia Planells, Sara Perez‐Jaume, Jaume Mora   +13 more
wiley   +1 more source

CopulaNet: Learning residue co-evolution directly from multiple sequence alignment for protein structure prediction

Nature Communications, 2021
Protein structure prediction is a challenge. A new deep learning framework, CopulaNet, is a major step forward toward end-to-end prediction of inter-residue distances and protein tertiary structures with improved accuracy and efficiency.
Fusong Ju, Jianwei Zhu, Bin Shao, Lupeng Kong, Tie-Yan Liu, Wei-Mou Zheng, Dongbo Bu   +6 more
doaj   +1 more source

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion [PDF]

, 2013
Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them.
Biggs, Caroline I., Cooper, A. (Amy), Dobrzanska, Dorota A., Dowson, Christopher G., Evans, Stephen D., Fox, David J., Johnson, Benjamin R., Marsh, Andrew, Randev, Rajan, Stec, Helena M., Taylor, Paul C.   +10 more
core   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Predicción computacional de la estructura terciaria de la iduronato 2-sulfato sulfatasa humana

Biomédica: revista del Instituto Nacional de Salud, 2007
Introducción. El síndrome de Hunter o mucopolisacaridosis tipo II (MC KUSIK 309900) es causado por la deficiencia de la iduronato 2-sulfato sulfatasa humana (E.C. 3.1.6.13).
Homero Sáenz, Leonardo Lareo, Raúl A. Poutou, Ángela C. Sosa, Luis A. Barrera   +4 more
doaj   +1 more source

Fast protein structure comparison through effective representation learning with contrastive graph neural networks.

PLoS Computational Biology, 2022
Protein structure alignment algorithms are often time-consuming, resulting in challenges for large-scale protein structure similarity-based retrieval.
Chunqiu Xia, Shi-Hao Feng, Ying Xia, Xiaoyong Pan, Hong-Bin Shen   +4 more
doaj   +1 more source