Results 61 to 70 of about 180,875 (351)

CONFOLD2: improved contact-driven ab initio protein structure modeling

BMC Bioinformatics, 2017
Contact-guided protein structure prediction methods are becoming more and more successful because of the latest advances in residue-residue contact prediction.
B. Adhikari, Jianlin Cheng
semanticscholar   +1 more source

Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction

, 2008
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represented as a machine learning problem, where neural networks are used to learn ...
Jones, DT, Tan Ching-Wai, Jones David T, Tan, CW   +3 more
core   +1 more source

Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold

Scientific Reports, 2023
The crystal structure of the domain of unknown function family 507 protein from Aquifex aeolicus is reported (AaDUF507, UniProt O67633, 183 residues). The structure was determined in two space groups (C2221 and P3221) at 1.9 Å resolution.
Cole E. McKay, Jianlin Cheng, John J. Tanner   +2 more
doaj   +1 more source

Bioinformatics analysis of LPD06283 protein of Rhodococcus opacus

Siliao yanjiu, 2023
The study was to investigate the structure and function of LPD06283 protein of Rhodococcus opacus PD630. Bioinformatics methods were used to analyze the physicochemical properties, hydrophilicity and hydrophobicity, amphiphilic α helix, homology, signal ...
MA Xue-jing, BAI Jing, HAN Jing-xuan, BAI Xiao-meng, HAN Ran, LI Bo-ying, HAO Ya-ru, ZHANG Zhao-ying   +7 more
doaj  

Cholesterol-mediated allosteric regulation of the mitochondrial translocator protein structure

Nature Communications, 2017
Cholesterol is an important regulator of membrane protein function. However, the exact mechanisms involved in this process are still not fully understood.
Garima Jaipuria, A. Leonov, Karin Giller, S. Vasa, Łukasz Jaremko, Mariusz Jaremko, R. Linser, S. Becker, M. Zweckstetter   +8 more
semanticscholar   +1 more source

Refinement of Protein Tertiary Structure by Using Spin-Spin Coupling Constants from Nuclear Magnetic Resonance Measurements

, 2012
Modelling protein structure seems a challenging enterprise because the number of structure parameters required ordinarily exceeds the amount of independent data points available from experimental observations. Expressing the predominant conformation of a
Schmidt, Jürgen M., Frank Lhr, Jrgen M., Jürgen M. Schmidt, Löhr, Frank, Frank Löhr   +5 more
core   +1 more source

In-Cell NMR Characterization of the Secondary Structure Populations of a Disordered Conformation of α-Synuclein within E. coli Cells. [PDF]

, 2013
α-Synuclein is a small protein strongly implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders. We report here the use of in-cell NMR spectroscopy to observe directly the structure and dynamics of this protein ...
Christopher A. Waudby (238969), A. W. P. Fitzpatrick, Cabrita, LD, Carlo Camilloni, C. A. Waudby, Cabrita Lisa D., Camilloni Carlo, Christodoulou, J, Waudby Christopher A., Christodoulou, John, John Christodoulou, Camilloni, C., Christopher M Dobson, Lisa D. Cabrita, Waudby, CA, Dobson Christopher M., Michele Vendruscolo (68357), Temussi, P.A., Lisa D Cabrita, Fitzpatrick, AW, Christopher M. Dobson, Christopher M. Dobson (181572), Fitzpatrick, A.W.P., Dobson, C.M., Anthony W. P. Fitzpatrick, John Christodoulou (450398), Dobson, CM, C. Camilloni, Cabrita, L.D., Vendruscolo, M, Anthony W. P. Fitzpatrick (450396), M. Vendruscolo, Carlo Camilloni (450395), Anthony W P Fitzpatrick, Lisa D. Cabrita (450397), L. D. Cabrita, Christodoulou John, C. M. Dobson, Waudby, Christopher A., J. Christodoulou, Camilloni, C, Fitzpatrick Anthony W. P., Christopher A Waudby, Michele Vendruscolo, Christopher A. Waudby, Vendruscolo Michele, Vendruscolo, M.   +46 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Parallel Geometric Hashing Algorithm For Protein Tertiary Structure. [PDF]

, 2007
The amount of protein structure has become very huge nowadays, which has led to the need for improving algorithms to cope with this exponential increase.
Jaber, Khalid, Abdullah, Rosni, Othman, Fazilah   +2 more
core  

Bioinformatics analysis of microalgal lipid droplet proteins

Siliao yanjiu, 2023
The experiment was to explore the structural features of microalgal lipid droplet proteins. Bioinformatics methods were used to investigate the physicochemical properties, hydrophilicity/hydrophobicity, signal peptide, transmembrane domain, amphipathic α-
MA Xue-jing, LIANG Meng-meng, CONG Hui, LIANG Yan-zhong, ZHANG Zheng-kai, GUO Zi-yue, WANG Jing-lin, ZHANG Zhao-ying   +7 more
doaj