Results 61 to 70 of about 317,356 (295)

Tertiary Structure of Uracil-DNA Glycosylase Inhibitor Protein [PDF]

Journal of Biological Chemistry, 1995
The Bacillus subtilis bacteriophage PBS2 uracil-DNA glycosylase inhibitor (Ugi) is an acidic protein of 84 amino acids that inactivates uracil-DNA glycosylase from diverse organisms. The secondary structure of Ugi consists of five anti-parallel beta-strands and two alpha-helices (Balasubramanian, S., Beger, R.D., Bennett, S.E., Mosbaugh, D.W., and ...
R D, Beger, S, Balasubramanian, S E, Bennett, D W, Mosbaugh, P H, Bolton   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A triphosphate tunnel metalloenzyme from pear (PbrTTM1) moonlights as an adenylate cyclase

Frontiers in Plant Science, 2023
Adenylyl cyclase (AC) is the vital enzyme for generating 3′,5′-cyclic adenosine monophosphate, an important signaling molecule with profound nutritional and medicinal values.
Ye Yuan, Yuye Liu, Shuangjiang Chen, Lili Wang, Lili Wang, Lixin Wang, Lixin Wang, Yahong Niu, Xin Zhao, Zhihui Zhao, Zhihui Zhao, Zhiguo Liu, Zhiguo Liu, Mengjun Liu, Mengjun Liu   +14 more
doaj   +1 more source

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion [PDF]

, 2013
Selective oxidation of omega-tertiary amine self-assembled thiol monolayers to tertiary amine N-oxides is shown to transform the adhesion of model proteins lysozyme and fibrinogen upon them.
Biggs, Caroline I., Cooper, A. (Amy), Dobrzanska, Dorota A., Dowson, Christopher G., Evans, Stephen D., Fox, David J., Johnson, Benjamin R., Marsh, Andrew, Randev, Rajan, Stec, Helena M., Taylor, Paul C.   +10 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The Mrs1 splicing factor binds the bI3 group I intron at each of two tetraloop-receptor motifs. [PDF]

PLoS ONE, 2010
Most large ribozymes require protein cofactors in order to function efficiently. The yeast mitochondrial bI3 group I intron requires two proteins for efficient splicing, Mrs1 and the bI3 maturase. Mrs1 has evolved from DNA junction resolvases to function
Caia D S Duncan, Kevin M Weeks
doaj   +1 more source

Statistical analysis of protein molecules [PDF]

, 2011
In this paper, entropy and auto-correlation values of main chain dihedral angles of 22,356 protein molecules are calculated and found to lie within a well-specified range for most proteins.
Kushal Shah
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A hybrid variational autoencoder and WGAN with gradient penalty for tertiary protein structure generation

Scientific Reports
Elucidating the tertiary structure of proteins is important for understanding their functions and interactions. While deep neural networks have advanced the prediction of a protein’s native structure from its amino acid sequence, the focus on a single ...
Aalaa I. Sehsah, Afaf Mousa, Gamal Farouk   +2 more
doaj   +1 more source