Results 21 to 30 of about 2,069,772 (318)

Subtype-Specific HIV-1 Protease and the Role of Hinge and Flap Dynamics in Drug Resistance: A Subtype C Narrative

Viruses
The HIV-1 aspartic protease is an effective target for the treatment of HIV/AIDS. Current therapy utilizes a selection of nine protease inhibitors (PIs) in combination with other classes of antiretroviral drugs.
Dean Sherry, Zaahida Sheik Ismail, Tshele Mokhantso, Yasien Sayed   +3 more
doaj   +1 more source

Degenerate cysteine patterns mediate two redox sensing mechanisms in the papillomavirus E7 oncoprotein

Redox Biology, 2017
Infection with oncogenic human papillomavirus induces deregulation of cellular redox homeostasis. Virus replication and papillomavirus-induced cell transformation require persistent expression of viral oncoproteins E7 and E6 that must retain their ...
Gabriela Camporeale, Juan R. Lorenzo, Maria G. Thomas, Edgardo Salvatierra, Silvia S. Borkosky, Marikena G. Risso, Ignacio E. Sánchez, Gonzalo de Prat Gay, Leonardo G. Alonso   +8 more
doaj   +1 more source

Structure of the human marker of self 5-transmembrane receptor CD47

Nature Communications, 2021
CD47 is a transmembrane receptor involved in the regulation of various signalling pathways and a promising target for immuno-oncology therapeutics. Here, the authors present the crystal structure of full-length human CD47 and provide insights into the ...
Gustavo Fenalti, Nicolas Villanueva, Mark Griffith, Barbra Pagarigan, Sirish Kaushik Lakkaraju, Richard Y.-C. Huang, Nadia Ladygina, Alok Sharma, David Mikolon, Mahan Abbasian, Jeffrey Johnson, Haralambos Hadjivassiliou, Dan Zhu, Philip P. Chamberlain, Ho Cho, Kandasamy Hariharan   +15 more
doaj   +1 more source

RuvC uses dynamic probing of the Holliday junction to achieve sequence specificity and efficient resolution

Nature Communications, 2019
Holliday junctions (HJs) are four-way DNA structures that occur in DNA repair by homologous recombination which are removed by nucleases such as RuvC. Here the authors provide structural and biochemical details on the steps required for the completion of
Karolina Maria Górecka, Miroslav Krepl, Aleksandra Szlachcic, Jarosław Poznański, Jiří Šponer, Marcin Nowotny   +5 more
doaj   +1 more source

Biotransformation of Lignin by an Artificial Heme Enzyme Designed in Myoglobin With a Covalently Linked Heme Group

Frontiers in Bioengineering and Biotechnology, 2021
The conversion of Kraft lignin in plant biomass into renewable chemicals, aiming at harvesting aromatic compounds, is a challenge process in biorefinery.
Wen-Jie Guo, Jia-Kun Xu, Jing-Jing Liu, Jia-Jia Lang, Shu-Qin Gao, Ge-Bo Wen, Ying-Wu Lin, Ying-Wu Lin   +7 more
doaj   +1 more source

Structure and Non-Structure of Centrosomal Proteins

PLoS ONE, 2013
Here we perform a large-scale study of the structural properties and the expression of proteins that constitute the human Centrosome. Centrosomal proteins tend to be larger than generic human proteins (control set), since their genes contain in average more exons (20.3 versus 14.6).
Dos Santos, Helena G., Abia, David, Janowski, Robert, Mortuza, Gulnahar, Bertero, Michela G., Boutin, Maïlys, Guarín, Nayibe, Méndez Giraldez, Raúl, Nuñez, Alfonso, Pedrero, Juan G., Redondo, Pilar, Sanz, María, Speroni, Silvia, Teichert, Florian, Bruix, Maria, Carazo, José M., González, Cayetano, Reina, José, Valpuesta, José M., Vernos, Isabelle, 1959-, Zabala, Juan C., Montoya, Guillermo, Coll, Miquel, Bastolla, Ugo, Serrano Pubull, Luis, 1982-   +24 more
openaire   +4 more sources

Nuclear VPS35 attenuates NHEJ repair by sequestering Ku protein

Molecular Medicine
Vacuolar protein sorting-associated protein 35 (VPS35), a pivotal constituent of the retromer complex, mediates the retrograde trafficking of endosomal cargoes in the cytoplasm.
Luping Zhang, Yonghong Nie, Tuo Tang, Yanji Lu, Wenlong Li, Xian Hong, Qiang Li, Aixue Zheng, Yongpei Li, Jianwen Zhou, Li Fan, Tao Wang, Zhihui Deng   +12 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A robust, deep learning-based analysis of time-domain signals for NMR spectroscopy

Journal of Analytical Science and Technology
When analyzing the Free Induction Decay (FID) signal produced by nuclear magnetic resonance (NMR) spectroscopy, Fourier transforms (FT) are used to decompose time-domain signals arising from nuclear interactions.
Kyungdoe Han, Eunhee Kim, Kyoung-Seok Ryu, Donghan Lee   +3 more
doaj   +1 more source