Results 21 to 30 of about 19,302,461 (314)
Molecular basis for protein histidine N1-specific methylation of the “His-x-His” motifs by METTL9
Cell Insight, 2023 Histidine methylation serves as an intriguing strategy to introduce altered traits of target proteins, including metal ion chelation, histidine-based catalysis, molecular assembly, and translation regulation.
Wentao Zhao +6 more
doaj +1 more source
PON-SC – program for identifying steric clashes caused by amino acid substitutions
BMC Bioinformatics, 2017 Background Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites.
Jelena Čalyševa, Mauno Vihinen
doaj +1 more source
Biomolecules, 2021 Glutathione transferases (GSTs) are the main detoxification enzymes in schistosomes. These parasitic enzymes tend to be upregulated during drug treatment, with Schistosoma haematobium being one of the species that mainly affect humans. There is a lack of
Neo Padi +5 more
doaj +1 more source
PredictProtein - Predicting Protein Structure and Function for 29 Years
bioRxiv, 2021 Since 1992 PredictProtein (https://predictprotein.org) is a one-stop online resource for protein sequence analysis with its main site hosted at the Luxembourg Centre for Systems Biomedicine (LCSB) and queried monthly by over 3,000 users in 2020 ...
Michael Bernhofer +27 more
semanticscholar +1 more source
Representativeness of variation benchmark datasets
BMC Bioinformatics, 2018 Background Benchmark datasets are essential for both method development and performance assessment. These datasets have numerous requirements, representativeness being one.
Gerard C. P. Schaafsma, Mauno Vihinen
doaj +1 more source
Cell-based assays to identify novel retinoprotective agents
MethodsX, 2020 Degeneration of the retina can lead ultimately to devastating irreversible vision loss, such as in inherited retinitis pigmentosa and age-related macular degeneration. Currently there is no cure to prevent retinal degeneration.
Jeanee Bullock +2 more
doaj +1 more source
Functional properties of individual sub-domains of the fibrin(ogen) αC-domains
BBA Advances, 2023 Background: Fibrinogen is a large polyfunctional plasma protein consisting of a number of structural and functional domains. Among them, two αC-domains, each formed by the amino acid residues Аα392–610, are involved in fibrin polymerization, activation ...
Y.M. Stohnii +10 more
doaj +1 more source
Highlights in BioScience, 2020 Genetic mutagenesis is a very efficient tool in studying genes function. Because of the great benefits of legumes as human food and animal feed worldwide, we used a model plant Medicago truncatula for identification gene function related to nitrogen ...
Asmaa Hamdy Hassan +2 more
doaj +1 more source
Deep Learning-Based Advances in Protein Structure Prediction
International Journal of Molecular Sciences, 2021 Obtaining an accurate description of protein structure is a fundamental step toward understanding the underpinning of biology. Although recent advances in experimental approaches have greatly enhanced our capabilities to experimentally determine protein ...
S. C. Pakhrin +3 more
semanticscholar +1 more source
Scientific Reports, 2022 We have recently developed a mouse monoclonal antibody (12–10H) binding to the head domain region in rat P2X4 receptor (rP2X4R, which is crucial for the pathogenesis of neuropathic pain) expressed on the cell with the highest binding affinity (K D = 20 ...
Chinatsu Shinozaki +11 more
doaj +1 more source