Results 61 to 70 of about 3,699,805 (346)
Protein thermodynamic structure [PDF]
IUBMB Life, 2009 AbstractProtein research is generally recognized as experimental science and knowledge of protein science is not constructed axiomatically. In this article, we show that much of our present knowledge of protein science is explainable by principles of protein thermodynamic structure theory. A deductive system for protein knowledge has been developed and
openaire +2 more sources
The Protein Structure Initiative Structural Genomics Knowledgebase [PDF]
The FASEB Journal, 2009 The Protein Structure Initiative (PSI) has produced more than 3300 protein structures in a high throughput manner. In order to achieve this, new technologies for all aspects of the structure determination and analysis pipeline have been developed.
Berman, H. M. +16 more
openaire +5 more sources
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
De novo design of protein minibinder agonists of TLR3
Nature CommunicationsToll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and ...
Chloe S. Adams +9 more
doaj +1 more source
Wnt signaling polarizes cortical actin polymerization to increase daughter cell asymmetry
Cell Discovery, 2022 Asymmetric positioning of the mitotic spindle contributes to the generation of two daughter cells with distinct sizes and fates. Here, we investigated an asymmetric division in the Caenorhabditis elegans Q neuroblast lineage.
Yongping Chai +7 more
doaj +1 more source
Two Rules on the Protein-Ligand Interaction [PDF]
, 2008 So far, we still lack a clear molecular mechanism to explain the protein-ligand interaction on the basis of electronic structure of a protein. By combining the calculation of the full electronic structure of a protein along with its hydrophobic pocket ...
Lily Zhang +4 more
core +1 more source
On the optimal contact potential of proteins
, 2007 We analytically derive the lower bound of the total conformational energy of a protein structure by assuming that the total conformational energy is well approximated by the sum of sequence-dependent pairwise contact energies.
Akira R. Kinjo +32 more
core +1 more source
Assessing functional novelty of PSI structures via structure-function analysis of large and diverse superfamilies [PDF]
, 2008 The structural genomics initiatives have had as one of their aims to improve our understanding of protein function by providing representative structures for many structurally uncharacterised protein families. As suggested by the recent assessment of the
Benoit H. Dessailly +2 more
core +2 more sources
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA
Nature CommunicationsNucleotide excision repair is a DNA repair pathway which detects and fixes various DNA lesions that distort the structure of DNA. In bacteria, the pathway starts with the UvrA protein which has two adenosine triphosphatase modules and forms dimers.
Shivlee Nirwal +5 more
doaj +1 more source