Results 101 to 110 of about 1,677,396 (366)

Protein structure prediction by AlphaFold2: are attention and symmetries all you need?

Acta Crystallographica Section D: Structural Biology, 2021
This review discusses the AlphaFold2 system for protein structure prediction, including its conceptual and methodological advances, its amenability to interpretation and its achievements in the last Critical Assessment of protein Structure Prediction ...
N. Bouatta, P. Sorger, Mohammed Alquraishi   +2 more
semanticscholar   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

FDserver: A web service for protein folding research [PDF]

, 2008
*Summary:* To facilitate the study of protein folding, we have developed a web service for protein folding rate and folding type prediction as well as for the calculation of a variety of topological parameters of protein structure, which is freely ...
Bin-Guang Ma, Hong-Yu Zhang, Ling-Ling Chen   +2 more
core   +1 more source

A probabilistic fragment-based protein structure prediction algorithm.

PLoS ONE, 2012
Conformational sampling is one of the bottlenecks in fragment-based protein structure prediction approaches. They generally start with a coarse-grained optimization where mainchain atoms and centroids of side chains are considered, followed by a fine ...
David Simoncini, Francois Berenger, Rojan Shrestha, Kam Y J Zhang   +3 more
doaj   +1 more source

Prediction of protein-destabilizing polymorphisms by manual curation with protein structure. [PDF]

PLoS ONE, 2012
The relationship between sequence polymorphisms and human disease has been studied mostly in terms of effects of single nucleotide polymorphisms (SNPs) leading to single amino acid substitutions that change protein structure and function.
Craig Alan Gough, Keiichi Homma, Yumi Yamaguchi-Kabata, Makoto K Shimada, Ranajit Chakraborty, Yasuyuki Fujii, Hisakazu Iwama, Shinsei Minoshima, Shigetaka Sakamoto, Yoshiharu Sato, Yoshiyuki Suzuki, Masahito Tada-Umezaki, Ken Nishikawa, Tadashi Imanishi, Takashi Gojobori   +14 more
doaj   +1 more source

JPred4: a protein secondary structure prediction server

Nucleic Acids Res., 2015
JPred4 (http://www.compbio.dundee.ac.uk/jpred4) is the latest version of the popular JPred protein secondary structure prediction server which provides predictions by the JNet algorithm, one of the most accurate methods for secondary structure prediction.
Alexey Drozdetskiy, C. Cole, J. Procter, G. Barton   +3 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

MUST-CNN: A Multilayer Shift-and-Stitch Deep Convolutional Architecture for Sequence-based Protein Structure Prediction

, 2016
Predicting protein properties such as solvent accessibility and secondary structure from its primary amino acid sequence is an important task in bioinformatics.
Lanchantin, Jack, Lin, Zeming, Qi, Yanjun   +2 more
core   +1 more source

WeFold: A coopetition for protein structure prediction [PDF]

Proteins: Structure, Function, and Bioinformatics, 2014
The protein structure prediction problem continues to elude scientists. Despite the introduction of many methods, only modest gains were made over the last decade for certain classes of prediction targets. To address this challenge, a social-media based worldwide collaborative effort, named WeFold, was undertaken by 13 labs.
Kefan Xu, Seth Cooper, James Smadbeck, David Baker, Jaume Bacardit, Rodrigo Antonio Faccioli, Leandro Oliveira Bortot, Zoran Popović, Jeff Flatten, Yi He, Alexandre C. B. Delbem, Paweł Krupa, Paweł Krupa, Chen Keasar, Xin Deng, Jilong Li, Michael Levitt, Harold A. Scheraga, Tomasz K Wirecki, Tomasz K Wirecki, Adam K. Sieradzan, Foldit Players, Gaurav Chopra, Gaurav Chopra, Hongyi Zhou, George A. Khoury, Silvia Crivelli, Christodoulos A. Floudas, Adam Liwo, Firas Khatib, Firas Khatib, Jianlin Cheng, Jeffrey Skolnick, Magdalena A. Mozolewska, Magdalena A. Mozolewska   +34 more
openaire   +4 more sources

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source