Results 171 to 180 of about 1,386,749 (339)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Recent Advances in NMR Protein Structure Prediction with ROSETTA. [PDF]

Int J Mol Sci, 2023
Koehler Leman J, Künze G.
europepmc   +1 more source

Efficient and accurate prediction of protein structure using RoseTTAFold2

bioRxiv, 2023
M. Baek, I. Anishchenko, Ian R. Humphreys, Qian Cong, D. Baker, F. DiMaio   +5 more
semanticscholar   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Protein structure prediction with energy minimization and deep learning approaches. [PDF]

Nat Comput, 2023
Filgueiras JL, Varela D, Santos J.
europepmc   +1 more source

ROTAS: a rotamer-dependent, atomic statistical potential for assessment and prediction of protein structures [PDF]

, 2014
Jungkap Park, Kazuhiro Saitou
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

A comprehensive application of FiveFold for conformation ensemble-based protein structure prediction. [PDF]

Sci Rep
Niazi SK, Yang J.
europepmc   +1 more source

3 = 1 + 2: how the divide conquered de novo protein structure prediction and what is next? [PDF]

Natl Sci Rev, 2023
Zhou Y, Litfin T, Zhan J.
europepmc   +1 more source