Method of the Year: protein structure prediction
Nature Methods, 2022 V. Marx
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper +5 more
wiley +1 more source
An end-to-end framework for the prediction of protein structure and fitness from single sequence
Nature CommunicationsSignificant research progress has been made in the field of protein structure and fitness prediction. Particularly, single-sequence-based structure prediction methods like ESMFold and OmegaFold achieve a balance between inference speed and prediction ...
Yinghui Chen +4 more
doaj +1 more source
Estimating the significance of sequence order in protein secondary structure and prediction [PDF]
, 2000 Jong Moon Park +3 more
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HPDL Variant Type Correlates With Clinical Disease Onset and Severity
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recently, a mitochondrial encephalopathy due to biallelic HPDL variants was described, associated with a broad range of clinical manifestations ranging from severe, infantile‐onset neurodegeneration to adolescence‐onset hereditary spastic paraplegia. HPDL converts 4‐hydroxyphenylpyruvate acid (4‐HPPA) into 4‐hydroxymandelate (4‐HMA),
Eun Hye Lee +19 more
wiley +1 more source
Multi-domain and complex protein structure prediction using inter-domain interactions from deep learning. [PDF]
Commun Biol, 2023 Xia Y, Zhao K, Liu D, Zhou X, Zhang G.
europepmc +1 more source
Constructing side chains on near-native main chains for ab initio protein structure prediction [PDF]
, 2000 Ram Samudrala +3 more
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Compound Heterozygous MRPS14 Variants Associated With Leigh Syndrome
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT MRPS14 (uS14m) is a nuclear‐encoded ribosomal protein important for mitochondria‐specific translation. To date, only a single individual with a recessive MRPS14‐related disorder (also known as COXPD38) has been reported. We report an additional subject possessing novel compound heterozygous MRPS14 variants (p.Asp37Asn, p.Asn60Asp). The subject
Maria Gabriela Otero +15 more
wiley +1 more source
Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study investigated myostatin levels in SMA patients receiving disease‐modifying therapies (DMTs) to understand their relationship with treatment duration and functional status. Methods Our study includes both cross‐sectional and longitudinal analyses of myostatin levels in treated SMA patients.
Fiorella Piemonte +23 more
wiley +1 more source
How to generate improved potentials for protein tertiary structure prediction: A lattice model study [PDF]
, 2000 Ting-Lan Chiu, Richard A. Goldstein
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