Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan+8 more
wiley +1 more source
Ab initio protein structure prediction: the necessary presence of external force field as it is delivered by Hsp40 chaperone. [PDF]
Roterman I, Stapor K, Konieczny L.
europepmc +1 more source
Influence of Dystrophin Isoform Deficiency on Motor Development in Duchenne Muscular Dystrophy
ABSTRACT Objective In Duchenne muscular dystrophy (DMD), lack of the shorter dystrophin isoforms Dp140 and Dp71 is associated with increased central nervous system (CNS) involvement. We aimed to investigate how CNS involvement affects motor development in young DMD boys.
Mary Chesshyre+152 more
wiley +1 more source
Protein secondary structure prediction by merged hidden Markov models [PDF]
Christian Cumbaa
openalex +1 more source
ABSTRACT Objective SCN1A‐related seizures first present as febrile seizures (FS). Definitive features emerge later, making early diagnosis challenging. We evaluated the diagnostic yield and clinical characteristics of pathogenic SCN1A variants in FS, and analyzed the effect of variant characteristics on clinical phenotypes required for early ...
Jia Wang+11 more
wiley +1 more source
Target-template relationships in protein structure prediction and their effect on the accuracy of thermostability calculations. [PDF]
Lihan M, Lupyan D, Oehme D.
europepmc +1 more source
New methods for accurate prediction of protein secondary structure
John‐Marc Chandonia, Martin Karplus
openalex +1 more source
EVA: continuous automatic evaluation of protein structure prediction servers [PDF]
Volker A. Eyrich+8 more
openalex +1 more source
Metabolic Consequences of Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) may have metabolic disruption, which can contribute to adverse long‐term outcomes, for multiple reasons. Patients with RA appear to have a higher risk of sarcopenia, type 1 and type 2 diabetes mellitus, metabolic syndrome, and hypertension. Systemic inflammation in RA can cause a “lipid paradox,” with reduced low‐
Stevie Barry+2 more
wiley +1 more source
Improving protein structure prediction using templates and sequence embedding. [PDF]
Wu F, Jing X, Luo X, Xu J.
europepmc +1 more source