Results 71 to 80 of about 1,677,396 (366)
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Introduction to Protein Structure Prediction [PDF]
, 2017 This chapter gives a graceful introduction to problem of protein three- dimensional structure prediction, and focuses on how to make structural sense out of a single input sequence with unknown structure, the 'query' or 'target' sequence.
Abeln, Sanne +2 more
core +1 more source
Predicting the outer membrane proteome of Pasteurella multocida based on consensus prediction enhanced by results integration and manual confirmation [PDF]
, 2012 Background Outer membrane proteins (OMPs) of Pasteurella multocida have various functions related to virulence and pathogenesis and represent important targets for vaccine development.
Burchmore, R. +3 more
core +3 more sources
Local protein structure prediction using discriminative models
BMC Bioinformatics, 2006 Background In recent years protein structure prediction methods using local structure information have shown promising improvements. The quality of new fold predictions has risen significantly and in fold recognition incorporation of local structure ...
Lengauer Thomas +2 more
doaj +1 more source
Acta Physica Sinica, 2016 Predicting 3D structure of proteins from the amino acid sequences is one of the most important unsolved problems in computational biology and biophysics. This review article attempts to introduce the most recent effort and progress on this problem. After a brief introduction of the background and basic concepts involved in protein structure prediction,
Jia Ya, Zhang Yang, Deng Hai-You
openaire +1 more source
Sisyphus and prediction of protein structure [PDF]
Bioinformatics, 1997 The problem of predicting protein structure from the sequence remains fundamentally unsolved despite more than three decades of intensive research effort. However, new and promising methods in three-dimensional (3D), 2D and 1D prediction have reopened the field.
Burkhard Rost, Seán I. O'Donoghue
openaire +3 more sources
FEBS Letters, EarlyView.Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa +8 more
wiley +1 more source
Optimized bio-inspired kernels with twin support vector machine using low identity sequences to solve imbalance multiclass classification [PDF]
, 2019 The function of enzymes is performed differently depending on their bio-chemical mechanisms and important to the prediction of protein structure and function.
Guramand, S.K. +5 more
core +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Bayesian models and algorithms for protein beta-sheet prediction [PDF]
, 2011 Prediction of the three-dimensional structure greatly benefits from the information related to secondary structure, solvent accessibility, and non-local contacts that stabilize a protein's structure.
Altunbasak, Yucel +5 more
core +1 more source