Results 91 to 100 of about 4,305,499 (240)

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

LOCATE: a mouse protein subcellular localization database

, 2006
We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set.
Kai, Chikatoshi, Davis, MJ, Kawai, J, Aturaliya, Rajith N., Teasdale, Melvena S., Teasdale, MS, Kawai, Jun, Carninci, P, Carninci, Piero, Teasdale, RD, Hayashizaki, Yoshihide, Teasdale, Rohan D., Hanson, K, Hayashizaki, Y, Zhang, Fasheng, Zhang, F, Davis, Melissa J., Fink, J. Lynn, Aturaliya, RN, Hanson, Kelly, Fink, JL, Kai, C   +21 more
core   +1 more source

Subdomain-specific localization of CLIMP-63 (p63) in the endoplasmic reticulum is mediated by its luminal alpha-helical segment [PDF]

, 2001
The microtubule-binding integral 63 kD cytoskeleton-linking membrane protein (CLIMP-63; former name, p63) of the rough endoplasmic reticulum (ER) is excluded from the nuclear envelope.
Klopfenstein, D. R., Viola Oorschot, Klumperman, J., Ariel Lustig, Richard A. Kammerer, Kammerer, Richard A., Hauri, H. P., Hans-Peter Hauri, Oorschot, Viola, Lustig, A., Klopfenstein, Dieter R., Kammerer, R. A., Lustig, Ariel, Hauri, Hans Peter, Judith Klumperman, Oorschot, V., Klumperman, Judith, Dieter R. Klopfenstein, Kammerer RA, Oorschot V, Klumperman J, Lustig A, Hauri HP, Klopfenstein DR   +23 more
core   +1 more source

Single‐Cell Resolution Mapping of Osteoarthritis‐Associated Chondrocyte Dynamics Using a High‐Density CMOS MEA Platform

Advanced Healthcare Materials, EarlyView.
Single‐cell and spatially resolved impedance mapping using a high‐density CMOS‐MEA platform enables non‐invasive monitoring of osteoarthritis‐associated chondrocyte dynamics. Continuous label‐free measurements reveal heterogeneous remodeling behaviors, including proliferation, migration, and phenotypic transitions, establishing a powerful approach for ...
Neha Deshpande, Pauline Coquart, Bram Theuns, Susanne Cremery, Jaime Rodolfo V. Garcia III, Julien Verplanken, Dennis Lambrechts, Dries Braeken, Liesbet Lagae, Johanna Bolander   +9 more
wiley   +1 more source

Computational prediction of protein subcellular localization and function [PDF]

, 2002
In this study, we present a computational approach in which it is possible to directly predict the protein functional categories from sequence and to identify the protein subcellular localization, which, in turn, is helpful for functional ...
Doğruel, Mutlu
core   +1 more source

CellMap visualizes protein-protein interactions and subcellular localization

, 2018
Many tools visualize protein-protein interaction (PPI) networks. The tool introduced here, CellMap, adds one crucial novelty by visualizing PPI networks in the context of subcellular localization, i.e.
Burkhard Rost, Tatyana Goldberg, Gregorio Alanis-Lobato, Christian Dallago, Miguel Angel Andrade-Navarro   +4 more
core   +1 more source

Atom‐Efficient Cerium‐Based Molecular Cages as Biocompatible Reactive Oxygen Scavengers

Advanced Healthcare Materials, EarlyView.
Discrete mixed‐valent cerium molecular cages organize accessible redox centers within confined coordination environments and scavenge superoxide, hydrogen peroxide, and hydroxyl radicals. Encapsulation of the lead cage in an ROS‐responsive DTP nanoplatform enables lesion‐associated delivery, attenuates macrophage oxidative stress and inflammation, and ...
Chao Li, Chunbai Xiang, Ye Xu, Yu Liu, Keze Hong, Fanchu Zeng, Gelin Xu, Zhao‐Xi Wang, Jonathan L. Sessler, Ping Gong   +9 more
wiley   +1 more source

Quantitative Proteomic Profiling of Low-Dose Ionizing Radiation Effects in a Human Skin Model

Proteomes, 2014
To assess responses to low-dose ionizing radiation (LD-IR) exposures potentially encountered during medical diagnostic procedures, nuclear accidents or terrorist acts, a quantitative proteomic approach was used to identify changes in protein abundance ...
Shawna M. Hengel, Joshua T. Aldrich, Katrina M. Waters, Ljiljana Pasa-Tolic, David L. Stenoien   +4 more
doaj   +1 more source

Novel AlkB Dioxygenases – Alternative Models for In Silico and In Vivo Studies [PDF]

, 2012
Background: ALKBH proteins, the homologs of Escherichia coli AlkB dioxygenase, constitute a direct, single-protein repair system, protecting cellular DNA and RNA against the cytotoxic and mutagenic activity of alkylating agents, chemicals significantly ...
Mielecki, Marcin, Zugaj, Dorota Łucja, Muszewska, Anna, Grzesiuk, Elzbieta, Mielecki, Damian, Grynberg, Marcin, Piwowarski, Jan, Nieminuszczy, Jadwiga, Chojnacka, Aleksandra   +8 more
core