Results 1 to 10 of about 101,248 (253)

Improving Protein Subcellular Location Classification by Incorporating Three-Dimensional Structure Information [PDF]

Biomolecules, 2021
The subcellular locations of proteins are closely related to their functions. In the past few decades, the application of machine learning algorithms to predict protein subcellular locations has been an important topic in proteomics.
Ge Wang, Yu-Jia Zhai, Zhen-Zhen Xue, Ying-Ying Xu   +3 more
doaj   +4 more sources

Consistency and variation of protein subcellular location annotations. [PDF]

Proteins, 2021
AbstractA major challenge for protein databases is reconciling information from diverse sources. This is especially difficult when some information consists of secondary, human‐interpreted rather than primary data. For example, the Swiss‐Prot database contains curated annotations of subcellular location that are based on predictions from protein ...
Xu YY, Zhou H, Murphy RF, Shen HB.
europepmc   +5 more sources

HAR_Locator: a novel protein subcellular location prediction model of immunohistochemistry images based on hybrid attention modules and residual units [PDF]

Frontiers in Molecular Biosciences, 2023
Introduction: Proteins located in subcellular compartments have played an indispensable role in the physiological function of eukaryotic organisms. The pattern of protein subcellular localization is conducive to understanding the mechanism and function ...
Kai Zou, Simeng Wang, Ziqian Wang, Zhihai Zhang, Fan Yang, Fan Yang   +5 more
doaj   +2 more sources

Prediction of apoptosis protein subcellular location based on amphiphilic pseudo amino acid composition [PDF]

Frontiers in Genetics, 2023
Introduction: Apoptosis proteins play an important role in the process of cell apoptosis, which makes the rate of cell proliferation and death reach a relative balance.
Wenxia Su, Shuyi Deng, Zhifeng Gu, Keli Yang, Hui Ding, Hui Chen, Zhaoyue Zhang, Zhaoyue Zhang   +7 more
doaj   +2 more sources

MIC_Locator: a novel image-based protein subcellular location multi-label prediction model based on multi-scale monogenic signal representation and intensity encoding strategy [PDF]

BMC Bioinformatics, 2019
Background Protein subcellular localization plays a crucial role in understanding cell function. Proteins need to be in the right place at the right time, and combine with the corresponding molecules to fulfill their functions. Furthermore, prediction of
Fan Yang, Yang Liu, Yanbin Wang, Zhijian Yin, Zhen Yang   +4 more
doaj   +2 more sources

PScL-HDeep: image-based prediction of protein subcellular location in human tissue using ensemble learning of handcrafted and deep learned features with two-layer feature selection. [PDF]

Brief Bioinform, 2021
Ullah M, Han K, Hadi F, Xu J, Song J, Yu DJ.   +5 more
europepmc   +2 more sources

Dual-Signal Feature Spaces Map Protein Subcellular Locations Based on Immunohistochemistry Image and Protein Sequence

Sensors, 2023
Protein is one of the primary biochemical macromolecular regulators in the compartmental cellular structure, and the subcellular locations of proteins can therefore provide information on the function of subcellular structures and physiological ...
Kai Zou, Simeng Wang, Ziqian Wang, Hongliang Zou, Fan Yang   +4 more
doaj   +1 more source

Automated classification of protein subcellular localization in immunohistochemistry images to reveal biomarkers in colon cancer

BMC Bioinformatics, 2020
Background Protein biomarkers play important roles in cancer diagnosis. Many efforts have been made on measuring abnormal expression intensity in biological samples to identity cancer types and stages.
Zhen-Zhen Xue, Yanxia Wu, Qing-Zu Gao, Liang Zhao, Ying-Ying Xu   +4 more
doaj   +1 more source

Using Evolutionary Information and Multi-Label Linear Discriminant Analysis to Predict the Subcellular Location of Multi-Site Bacterial Proteins via Chou’s 5-Steps Rule

IEEE Access, 2020
The function of a protein is closely tied to its subcellular location. Identifying the subcellular location of proteins is a crucial step to understand their functions.
Lei Du, Qingfang Meng, Hui Jiang, Yang Li   +3 more
doaj   +1 more source

Subcellular location prediction of apoptosis proteins using two novel feature extraction methods based on evolutionary information and LDA

BMC Bioinformatics, 2020
Background Apoptosis, also called programmed cell death, refers to the spontaneous and orderly death of cells controlled by genes in order to maintain a stable internal environment.
Lei Du, Qingfang Meng, Yuehui Chen, Peng Wu   +3 more
doaj   +1 more source