Results 11 to 20 of about 101,248 (253)
Fluorescence Intensity of Protein Tags Is Dependent on Their Subcellular Location
CellsFluorescent protein (FP) tagging is widely used in imaging experiments to investigate the subcellular distribution of proteins. However, because the fluorescence of most FP chromophores is quenched upon their protonation, their fluorescence intensities ...
Yan Chen +4 more
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Location, location, location: subcellular protein partitioning in proteostasis and aging [PDF]
Biophysical Reviews, 2021 AbstractSomatic maintenance and cell survival rely on proper protein homeostasis to ensure reliable functions across the cell and to prevent proteome collapse. Maintaining protein folding and solubility is central to proteostasis and is coordinated by protein synthesis, chaperoning, and degradation capacities.
Anita V. Kumar, Louis R. Lapierre
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Protein subcellular location prediction [PDF]
Protein Engineering, Design and Selection, 1999 The function of a protein is closely correlated with its subcellular location. With the rapid increase in new protein sequences entering into data banks, we are confronted with a challenge: is it possible to utilize a bioinformatic approach to help expedite the determination of protein subcellular locations?
K C, Chou, D W, Elrod
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Protein-protein interaction as a predictor of subcellular location [PDF]
BMC Systems Biology, 2009 AbstractBackgroundMany biological processes are mediated by dynamic interactions between and among proteins. In order to interact, two proteins must co-occur spatially and temporally. As protein-protein interactions (PPIs) and subcellular location (SCL) are discoveredviaseparate empirical approaches, PPI and SCL annotations are independent and might ...
Chang Shin +3 more
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LOCATE: a mammalian protein subcellular localization database [PDF]
Nucleic Acids Research, 2007 LOCATE is a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of mouse and human proteins. Over the past 2 years, the data in LOCATE have grown substantially. The database now contains high-quality localization data for 20% of the mouse proteome and general localization annotation for ...
Josefine Sprenger +5 more
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Plant-mPLoc: a top-down strategy to augment the power for predicting plant protein subcellular localization. [PDF]
PLoS ONE, 2010 One of the fundamental goals in proteomics and cell biology is to identify the functions of proteins in various cellular organelles and pathways. Information of subcellular locations of proteins can provide useful insights for revealing their functions ...
Kuo-Chen Chou, Hong-Bin Shen
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IEEE Access, 2023 Understanding where proteins are located within the cells is essential for proteomics research. Knowledge of protein subcellular location aids in early disease detection and drug targeting treatments. Incorrect localization of proteins can interfere with
Sonam Aggarwal +5 more
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BMC Bioinformatics, 2006 Background The subcellular location of a protein is closely related to its function. It would be worthwhile to develop a method to predict the subcellular location for a given protein when only the amino acid sequence of the protein is known.
Eils Roland, Bulashevska Alla
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Predicting human protein subcellular locations by the ensemble of multiple predictors via protein-protein interaction network with edge clustering coefficients. [PDF]
PLoS ONE, 2014 One of the fundamental tasks in biology is to identify the functions of all proteins to reveal the primary machinery of a cell. Knowledge of the subcellular locations of proteins will provide key hints to reveal their functions and to understand the ...
Pufeng Du, Lusheng Wang
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LOCATE: a mouse protein subcellular localization database [PDF]
Nucleic Acids Research, 2006 We present here LOCATE, a curated, web-accessible database that houses data describing the membrane organization and subcellular localization of proteins from the FANTOM3 Isoform Protein Sequence set. Membrane organization is predicted by the high-throughput, computational pipeline MemO. The subcellular locations of selected proteins from this set were
J. Lynn Fink +10 more
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