Results 121 to 130 of about 4,305,499 (240)

An Automated Combination of Sequence Motif Kernels for Protein Subcellular Localization

open access: yes, 2006
We propose an elegant multiclass prediction approach for protein subcellular localization. First we define a family of protein sequence kernels which consider variable length motifs with gaps.
Ong, C. ; https://orcid.org/, Zien, A.
core   +1 more source

Subcellular localization prediction pipeline.

open access: yes, 2016
Schematic representation of the implemented subcellular localization prediction pipeline for Phaeodactylum tricornutum adapted from previous work [57]. Subcellular compartments are given in ellipses and bioinformatics programs are displayed in rectangles.
Jared Broddrick (2735041)   +9 more
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

open access: yesAdvanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao   +7 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

open access: yesAdvanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green   +15 more
wiley   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

open access: yesAdvanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li   +8 more
wiley   +1 more source

A method to improve protein subcellular localization prediction by integrating various biological data sources

open access: yesBMC Bioinformatics, 2009
Background Protein subcellular localization is crucial information to elucidate protein functions. Owing to the need for large-scale genome analysis, computational method for efficiently predicting protein subcellular localization is highly required ...
Lee Doheon, Tung Thai
doaj   +1 more source

Ensemble of Multiple Classifiers for Multilabel Classification of Plant Protein Subcellular Localization. [PDF]

open access: yesLife (Basel), 2021
Wattanapornprom W   +3 more
europepmc   +1 more source

The subcellular localization of OsFdC2 protein.

open access: yes, 2015
The subcellular localization vector contained the C-terminal amino acids of FdC2 and GFP with the 35S promoter. GFP signals of the p35s::FdC2::GFP fusion protein localized in the chloroplast by transformation into rice protoplasts and empty GFP vector ...
Shujing Kang (830061)   +16 more
core   +1 more source

Gm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice

open access: yesAdvanced Science, EarlyView.
The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang   +12 more
wiley   +1 more source

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