Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. [PDF]
Mammalian voltage-gated K+ channels are assemblies of pore-forming alpha-subunits and modulating beta-subunits. To operate correctly, Kv4 alpha-subunits in the heart and central nervous system require recently identified beta-subunits of the neuronal ...
Butler, Margaret H+5 more
core
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Research progress of the Elongator complex in plant
The Elongator complex consists of six subunits (ELP1-ELP6), where ELP1-ELP3 forms the core subcomplex and ELP4-ELP6 forms the auxiliary subcomplex. Deletion of any of the six subunits results in an almost identical phenotype, suggesting that all six ...
Ji XIANGZHUO+4 more
doaj +1 more source
The site of synthesis of the iron-sulfur subunits of the flavoprotein and iron-protein fractions of human NADH dehydrogenase [PDF]
The site of synthesis of the iron-sulfur subunits of the flavoprotein and iron-protein fractions of the human respiratory chain NADH dehydrogenase has been investigated to test the possibility that any of them is synthesized in mitochondria.
Attardi, Giuseppe+4 more
core
Developments in plant breeding for improved nutritional quality of soya beans I. Protein and amino acid content [PDF]
Soya beans, like other legumes, contain low concentrations of the nutritionally essential sulphur amino acid, methionine. Cysteine, although not an essential amino acid because it can be synthesized from methionine, also influences the nutritional ...
Clarke, E, Wiseman, J
core +1 more source
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Distinct forebrain and cerebellar isozymes of type II Ca^(2+)/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction [PDF]
Forebrain and cerebellar Type II Ca2+/calmodulin-dependent protein kinases have different subunit compositions. The forebrain holoenzyme, characterized in our laboratory, is a 650-kDa holoenzyme composed of 50-kDa alpha-subunits and 60-kDa beta-subunits ...
Kennedy, Mary B., Miller, Stephen G.
core
Biogenesis of mitochondrial ubiquinol [PDF]
The precursor proteins to the subunits of ubiquinol:cytochrome c reductase (cytochrome bc1 complex) of Neurospora crassa were synthesized in a reticulocyte lysate.
Neupert, Walter+3 more
core +1 more source
Social context prevents heat hormetic effects against mutagens during fish development
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere+5 more
wiley +1 more source
Protein complex Arp2/3 has a conserved role in the nucleation of branched actin filaments. It is constituted of seven subunits, including actin-like subunits ARP2 and ARP3 plus five other subunits called Arp2/3 Complex Component 1 to 5, which are not ...
Erica Bellinvia+6 more
doaj +1 more source