Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Oligomerization and cell surface expression of recombinant GABAA receptors tagged in the δ subunit
Journal of Integrative Neuroscience, 2019 The γ-Aminobutyric acid type A receptors (GABAARs) are heteropentameric chloride channels responsible for primary inhibition in the mammalian brain.
Furkan Enes Oflaz +2 more
doaj +1 more source
VALYL-TRNA SYNTHETASE INTERACTS WITH Β-SUBUNIT OF THE EUKARYOTIC TRANSLATION ELONGATION FACTOR COMPLEX eEF1B [PDF]
Biotechnologia ActaThe aim of this study was to investigate the interaction of the N-terminal domain of the valyl-tRNA synthetase with α, β, and γ subunits of the eEF1B translation elongation factor complex.
N.T. KOLODKA +2 more
doaj +1 more source
Shared protein complex subunits contribute to explaining disrupted co-occurrence. [PDF]
PLoS Computational Biology, 2013 The gene composition of present-day genomes has been shaped by a complicated evolutionary history, resulting in diverse distributions of genes across genomes.
Adrian Schneider +2 more
doaj +1 more source
Functional modulation of the transient outward current Ito by KCNE beta-subunits and regional distribution in human non-failing and failing hearts [PDF]
, 2006 Objectives: The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I,, in human heart, can be modulated by several accessory subunits such as KChIP2 and KCNE1-KCNE5.
Banse, U. +8 more
core +1 more source
G Protein Subunits and Cell Proliferation
Neurosignals, 1998 Heterotrimeric, guanine nucleotide binding proteins, known as G proteins, provide signaling mechanisms for the serpentine family of receptors. Recent studies indicate that the alpha- as well as the beta gamma-subunits of the G proteins are involved in the regulation of several cellular responses.
N, Dhanasekaran, M V, Prasad
openaire +2 more sources
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
A Computational Framework for Predicting Direct Contacts and Substructures within Protein Complexes
Biomolecules, 2019 Understanding the physical arrangement of subunits within protein complexes potentially provides valuable clues about how the subunits work together and how the complexes function.
Suyu Mei, Kun Zhang
doaj +1 more source
Distinct forebrain and cerebellar isozymes of type II Ca^(2+)/calmodulin-dependent protein kinase associate differently with the postsynaptic density fraction [PDF]
, 1985 Forebrain and cerebellar Type II Ca2+/calmodulin-dependent protein kinases have different subunit compositions. The forebrain holoenzyme, characterized in our laboratory, is a 650-kDa holoenzyme composed of 50-kDa alpha-subunits and 60-kDa beta-subunits ...
Kennedy, Mary B., Miller, Stephen G.
core
The Crystal Structure of Monovalent Streptavidin. [PDF]
, 2016 The strong interaction between streptavidin (SA) and biotin is widely utilized in biotechnological applications. A SA variant, monovalent SA, was developed with a single and high affinity biotin-binding site within the intact tetramer.
Biswas, Sangita +3 more
core +1 more source