mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
Nature Communications, 2021 Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly.
Yilei Zhang +16 more
semanticscholar +1 more source
Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
Nature Communications, 2021 RaPID (Random non-standard Peptides Integrated Discovery) enables discovery of small macrocyclic peptides binding desired targets. Here, the authors propose lasso-grafting: the RaPID-derived peptides are implanted onto diverse proteins and maintain both ...
Emiko Mihara +12 more
doaj +1 more source
Structural mechanism of laminin recognition by integrin
Nature Communications, 2021 Recognition of laminin by integrin receptors mediates epithelial cell adhesion to basement membrane. Here, the structures of the α6β1 integrin alone and in complex with three-chain laminin-511 fragment reveal the laminin-integrin interface in molecular ...
Takao Arimori +7 more
doaj +1 more source
Rapid measurement of heteronuclear transverse relaxation rates using non-uniformly sampled R1ρ accordion experiments [PDF]
Magnetic Resonance, 2021 Multidimensional, heteronuclear NMR relaxation methods are used extensively to characterize the dynamics of biological macromolecules. Acquisition of relaxation datasets on proteins typically requires significant measurement time, often several days ...
S. Wernersson +3 more
doaj +1 more source
Functional role of the Frizzled linker domain in the Wnt signaling pathway
Communications Biology, 2022 The linker domain of Frizzled receptors has a varying effect on the functional levels of canonical and non-canonical Wnt signaling, with FZD chimeras influencing the binding of Wnt proteins and the recruitment of proteins regulating downstream signaling.
Seung-Bum Ko +7 more
doaj +1 more source
Interrelationship between contractility, protein synthesis and metabolism in mantle of juvenile cuttlefish (Sepia officinalis) [PDF]
, 2019 Young juvenile cuttlefish (Sepia officinalis) can grow at rates as high as 12% body weight per day. How the metabolic demands of such a massive growth rate impacts muscle performance that competes for ATP is unknown.
Bamford +49 more
core +1 more source
Cell Reports, 2012 Polymorphic adhesion molecules neurexin and neuroligin (NL) mediate asymmetric trans-synaptic adhesion, which is crucial for synapse development and function.
Hiroki Tanaka +5 more
doaj +1 more source
Roles of transcriptional and translational control mechanisms in regulation of ribosomal protein synthesis in Escherichia coli [PDF]
, 2017 Bacterial ribosome biogenesis is tightly regulated to match nutritional conditions and to prevent formation of defective ribosomal particles. InEscherichia coli, most ribosomal protein (r-protein) synthesis is coordinated with rRNA synthesis by a ...
Burgos, Hector L +3 more
core +3 more sources
Artificial photosynthetic cell producing energy for protein synthesis
Nature Communications, 2019 Attempts to construct an artificial cell have widened our understanding of living organisms. Many intracellular systems have been reconstructed by assembling molecules, however the mechanism to synthesize its own constituents by self-sufficient energy ...
Samuel Berhanu, T. Ueda, Yutetsu Kuruma
semanticscholar +1 more source