Results 21 to 30 of about 1,784,597 (218)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Transcriptome-wide analysis of the function of Ded1 in translation preinitiation complex assembly in a reconstituted in vitro system

eLife
We have developed a deep sequencing-based approach, Rec-Seq, that allows simultaneous monitoring of ribosomal 48S preinitiation complex (PIC) formation on every mRNA in the translatome in an in vitro reconstituted system. Rec-Seq isolates key early steps
Fujun Zhou, Julie M Bocetti, Meizhen Hou, Daoming Qin, Alan G Hinnebusch, Jon R Lorsch   +5 more
doaj   +1 more source

RETRACTED ARTICLE: Functionalized graphene oxide nanosheets with folic acid and silk fibroin as a novel nanobiocomposite for biomedical applications

Scientific Reports, 2022
In this paper, a novel graphene oxide-folic acid/silk fibroin (GO-FA/SF) nanobiocomposite scaffold was designed and fabricated using affordable and non-toxic materials.
Reza Eivazzadeh-Keihan, Farkhondeh Alimirzaloo, Hooman Aghamirza Moghim Aliabadi, Ehsan Bahojb Noruzi, Ali Reza Akbarzadeh, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi   +7 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Temperature-dependent regulation of upstream open reading frame translation in S. cerevisiae

BMC Biology, 2019
Background Translation of an mRNA in eukaryotes starts at an AUG codon in most cases, but near-cognate codons (NCCs) such as UUG, ACG, and AUU can also be used as start sites at low levels in Saccharomyces cerevisiae.
Shardul D. Kulkarni, Fujun Zhou, Neelam Dabas Sen, Hongen Zhang, Alan G. Hinnebusch, Jon R. Lorsch   +5 more
doaj   +1 more source

Inter-residue through-space scalar ¹⁹F–¹⁹F couplings between CH₂F groups in a protein [PDF]

Magnetic Resonance
Using cell-free protein synthesis, the protein G B1 domain (GB1) was prepared with uniform high-level substitution of leucine by (2S,4S)-5-fluoroleucine (FLeu1), (2S,4R)-5-fluoroleucine (FLeu2), or 5,5′-difluoroleucine (diFLeu).
Y. J. Tan, E. H. Abdelkader, I. D. Herath, A. Maleckis, G. Otting   +4 more
doaj   +1 more source

Effect of Acute Low-load High-repetition Resistance Exercise on Protein Synthetic Signaling Pathway and Satellite Cell Activation in Skeletal Muscle of Rats [PDF]

운동과학, 2020
PURPOSE Previous studies have reported that low-load high-repetition (LLHR) resistance exercise can induce muscle hypertrophy to a similar extent as high-load low-repetition (HLLR).
Chang-Hyun Lim, Chang-Keun Kim
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source