Results 21 to 30 of about 11,322,924 (398)

Quercetin 3, 3′, 4′, 5, 7-O- pentasulfate (QPS): A novel activator of protein disulfide isomerase

Medicine in Drug Discovery, 2020
Aims: Design and synthesis of a novel 3, 3′, 4′, 5, 7-O- pentasulfated Quercetin (QPS) as an activator of protein disulfide isomerase (PDI). Main Methods: Based on an in silico analysis we show that QPS binds to a and b domain of PDI (−7.4 kcal/mol ...
Abdul Burhan Khan, Neha Gupta, Qudsia Rashid, Irshad Ahmad, Shadabi Bano, Urfi Siddiqui, Mohammad Abid, Mohamad Aman Jairajpuri   +7 more
doaj   +1 more source

The synthesis of hemoglobin in a cell-free system [PDF]

, 1958
The microsomal particles (1) have been implicated as the major sites of protein synthesis within the cells of a variety of tissues. The studies of Borsook, Zamecnik, Hultin, and others, with intact animals and various types of whole cell systems (see ...
Allen, Esther, Lamfrom, Hildegarde, Schweet, Richard   +2 more
core   +2 more sources

Modest Declines in Proteome Quality Impair Hematopoietic Stem Cell Self-Renewal. [PDF]

, 2020
Low protein synthesis is a feature of somatic stem cells that promotes regeneration in multiple tissues. Modest increases in protein synthesis impair stem cell function, but the mechanisms by which this occurs are largely unknown.
Chua, Bernadette A, Dillingham, Christopher H, Hatters, Danny M, Hidalgo San Jose, Lorena, Hong, Yuning, Kruta, Miriama, Signer, Robert AJ, Sunshine, Mary Jean   +7 more
core   +1 more source

Identification of the growth arrest and DNA damage protein GADD34 in the normal human heart and demonstration of alterations in expression following myocardial ischaemia [PDF]

, 2006
Growth arrest and DNA damage protein 34 (GADD34) is a multifunctional protein upregulated in response to cellular stress and is believed to mediate DNA repair and restore protein synthesis. In the present study we have examined GADD34 immunoreactivity in
Brown, C. McCabe, Chou, Doutheil, E. Morton, F. White, Fornace, Hannan, Harland, He, Hollander, Horman, I.M. Macrae, Imai, S.M. Brown, White   +15 more
core   +1 more source

Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids

Nature Communications, 2018
Cell-free protein synthesis has emerged as a powerful approach for expanding the range of genetically encoded chemistry into proteins. Unfortunately, efforts to site-specifically incorporate multiple non-canonical amino acids into proteins using crude ...
Rey W Martin, B. D. Des Soye, Yong-Chan Kwon, Jennifer E. Kay, Roderick G Davis, P. Thomas, Natalia I. Majewska, Cindy X. Chen, Ryan D. Marcum, Mary Grace Weiss, Ashleigh E. Stoddart, M. Amiram, Arnaz K. Ranji Charna, Jaymin R. Patel, Farren J. Isaacs, N. Kelleher, S. Hong, M. Jewett   +17 more
semanticscholar   +1 more source

RETRACTED ARTICLE: A novel, bioactive and antibacterial scaffold based on functionalized graphene oxide with lignin, silk fibroin and ZnO nanoparticles

Scientific Reports, 2022
In this study, a novel nanobiocomposite was synthesized using graphene oxide, lignin, silk fibroin and ZnO and used in biological fields. To synthesize this structure, after preparing graphene oxide by the Hummer method, lignin, silk fibroin, and ZnO ...
Reza Eivazzadeh-Keihan, Ensiye Zare-Bakheir, Hooman Aghamirza Moghim Aliabadi, Mostafa Ghafori Gorab, Hossein Ghafuri, Ali Maleki, Hamid Madanchi, Mohammad Mahdavi   +7 more
doaj   +1 more source

Hsp70 in mitochondrial biogenesis [PDF]

, 1994
The family of hsp70 (70 kilodalton heat shock protein) molecular chaperones plays an essential and diverse role in cellular physiology, Hsp70 proteins appear to elicit their effects by interacting with polypeptides that present domains which exhibit non ...
A. Tzagoloff, A. Tzagoloff, A.J. Caplan, A.J. Caplan, B.D. Gambill, B.S. Glick, C.K. Suzuki, D. Ang, D. M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.M. Cyr, D.P. Atencio, E. Ikeda, E. Kutejová, E.A. Craig, E.A. Craig, F.-U. Hartl, G.S.P. Groot, H.R.B. Pelham, J. Ostermann, J. Rassow, J.F. Dice, J.P. Hendrick, K. Liberek, L. Dyck van, M. Eilers, M. Kiebler, M. Schleyer, M.-J. Gething, M.Y. Cheng, N. Rowley, N. Wang, P. Borst, P. Terpstra, P.-J. Kang, R. A. Stuart, R.A. Stuart, R.A. Stuart, R.B. Deshaies, R.G. Hadikusumo, R.J. Nelson, R.P. Beckman, S. Lindquist, S. Rospert, S.T. Hwang, T. Langer, U.C. Manning-Krieg, W. Neupert, W. Neupert, W. Voos, W.J. Chirico, Z. Xia   +53 more
core   +1 more source

Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. [PDF]

, 2016
Cellular amino acid uptake is critical for mTOR complex 1 (mTORC1) activation and cell proliferation. However, the regulation of amino acid uptake is not well-understood.
Braas, Daniel, Christofk, Heather R, Graeber, Thomas G, Krall, Abigail S, Xu, Shili   +4 more
core   +1 more source

Branched-chain amino acids and muscle protein synthesis in humans: myth or reality?

Journal of the International Society of Sports Nutrition, 2017
The branched chain amino acids (BCAAs) are leucine, valine and isoleucine. A multi-million dollar industry of nutritional supplements has grown around the concept that dietary supplements of BCAAs alone produce an anabolic response in humans driven by a ...
R. Wolfe
semanticscholar   +1 more source

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

Cell Reports, 2015
Membrane trafficking of integrins plays a pivotal role in cell proliferation and migration. How endocytosed integrins are targeted either for recycling or lysosomal delivery is not fully understood.
Dmitri Kharitidi, Pirjo M. Apaja, Sanaz Manteghi, Kei Suzuki, Elena Malitskaya, Ariel Roldan, Marie-Claude Gingras, Junichi Takagi, Gergely L. Lukacs, Arnim Pause   +9 more
doaj   +1 more source