Results 51 to 60 of about 13,924,024 (337)
Single-cell western blotting. [PDF]
, 2014 To measure cell-to-cell variation in protein-mediated functions, we developed an approach to conduct ∼10(3) concurrent single-cell western blots (scWesterns) in ∼4 h.
Herr, Amy E +5 more
core +2 more sources
Properties of protein drug target classes.
PLoS ONE, 2015 Accurate identification of drug targets is a crucial part of any drug development program. We mined the human proteome to discover properties of proteins that may be important in determining their suitability for pharmaceutical modulation.
Simon C Bull, Andrew J Doig
doaj +1 more source
Aptamer-based cell-free detection system to detect target protein
Synthetic and Systems Biotechnology, 2021 Biomarkers of disease, especially protein, show great potential for diagnosis and prognosis. For detecting a certain protein, a binding assay implementing antibodies is commonly performed.
Junhong Chen +6 more
doaj +1 more source
Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]
, 1978 INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro +12 more
core +1 more source
Protein-Targeting Drug Discovery
Biomolecules, 2023 Protein-driven biological processes play a fundamental role in biomedicine because they are related to pathologies of enormous social impact, such as cancer, neuropathies, and viral diseases, including the one at the origin of the recent COVID-19 pandemic [...]
Vicidomini Caterina, Roviello Giovanni
openaire +5 more sources
An Evolutionary Approach to Drug-Design Using Quantam Binary Particle Swarm Optimization Algorithm
, 2012 The present work provides a new approach to evolve ligand structures which represent possible drug to be docked to the active site of the target protein. The structure is represented as a tree where each non-empty node represents a functional group.
Chowdhury, Arkabandhu +3 more
core +1 more source
Zn(II)-curc targets p53 in thyroid cancer cells [PDF]
, 2015 P53 mutation is a common event in many cancers, including thyroid carcinoma. Defective p53 activity promotes cancer resistance to therapies and a more malignant phenotype, acquiring oncogenic functions.
Crispini, Alessandra +3 more
core +2 more sources
PROTAC targeted protein degraders: the past is prologue
Nature reviews. Drug discovery, 2022 Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules.
M. Békés, D. Langley, C. Crews
semanticscholar +1 more source
Targeting proteins for degradation [PDF]
Nature Chemical Biology, 2009 Protein degradation plays a central role in many cellular functions. Misfolded and damaged proteins are removed from the cell to avoid toxicity. The concentrations of regulatory proteins are adjusted by degradation at the appropriate time. Both foreign and native proteins are digested into small peptides as part of the adaptive immune response.
Erin K, Schrader +2 more
openaire +2 more sources
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53 [PDF]
, 2010 Background: The availability of various "omics" datasets creates a prospect of performing the study of genome-wide genetic regulatory networks. However, one of the major challenges of using mathematical models to infer genetic regulation from microarray ...
A Chipperfield +46 more
core +4 more sources