Results 261 to 270 of about 1,981,418 (307)
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Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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Drugs Targeting Protein—Protein Interactions
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
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Targeted protein degradation mechanisms
Drug Discovery Today: Technologies, 2019Targeted protein degradation mediated by small molecule degraders represents an exciting new therapeutic opportunity to eliminate disease-causing proteins. These molecules recruit E3 ubiquitin ligases to the protein of interest and mediate its ubiquitination and subsequent proteolysis by the proteasome.
Yi, Zhang +3 more
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Targeting of lysosomal proteins
Seminars in Cell & Developmental Biology, 2000Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN.
Y, Rouillé, W, Rohn, B, Hoflack
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Protein targeting to peroxisomes
Biochemical Society Transactions, 1990Peroxisomes are single-membrane-bound organelles that have important functions in cell metabolism. They are almost ubiquitous in eukaryotic cells and biochemical findings over the past 10 years have shown that they are involved in cell respiration, and also play a significant role in lipid metabolism (for reviews, see [ l , 21).
G M, Small, A S, Lewin
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Monomeric Targeted Protein Degraders
Journal of Medicinal Chemistry, 2020The discovery and development of targeted protein degraders have become important areas of research in the field of medicinal chemistry. Inducing degradation of a target protein presents several advantages relative to simple inhibition including a potential for extended duration of action and more profound pharmacology.
Emily J. Hanan +5 more
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Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Protein–Protein Interactions as Drug Targets
Future Medicinal Chemistry, 2015Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata +1 more
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Proteolysis-targeting Chimeras for Targeting Protein for Degradation
Future Medicinal Chemistry, 2019Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
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SnapShot: Targeted protein degradation
CellTargeted protein degradation strategies leverage endogenous cellular degradation machinery to selectively eliminate a protein of interest. Emerging technologies are opening avenues in drug discovery and functional characterization of intracellular, membrane, and extracellular proteins. To view this SnapShot, open or download the PDF.
Yu, Ding, Boxun, Lu
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