Results 61 to 70 of about 8,268,147 (364)

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Alternative trafficking of Weibel‐Palade body proteins in CRISPR/Cas9‐engineered von Willebrand factor–deficient blood outgrowth endothelial cells

Research and Practice in Thrombosis and Haemostasis, 2019
Background Synthesis of the hemostatic protein von Willebrand factor (VWF) drives formation of endothelial storage organelles called Weibel‐Palade bodies (WPBs).
Maaike Schillemans, Marije Kat, Jurjen Westeneng, Anastasia Gangaev, Menno Hofman, Benjamin Nota, Floris P. J. van Alphen, Martin de Boer, Maartje van den Biggelaar, Coert Margadant, Jan Voorberg, Ruben Bierings   +11 more
doaj   +1 more source

Fibrin Networks Regulate Protein Transport during Thrombus Development

PLoS Comput. Biol., 2013
Thromboembolic disease is a leading cause of morbidity and mortality worldwide. In the last several years there have been a number of studies attempting to identify mechanisms that stop thrombus growth.
O. Kim, Zhiliang Xu, E. Rosen, M. Alber
semanticscholar   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

ApoA-I Milano stimulates lipolysis in adipose cells independently of cAMP/PKA activation

Journal of Lipid Research, 2015
ApoA-I, the main protein component of HDL, is suggested to be involved in metabolic homeostasis. We examined the effects of Milano, a naturally occurring ApoA-I variant, about which little mechanistic information is available.
Maria Lindahl, Jitka Petrlova, Jonathan Dalla-Riva, Sebastian Wasserstrom, Catarina Rippe, Joan Domingo-Espin, Dorota Kotowska, Ewa Krupinska, Christine Berggreen, Helena A. Jones, Karl Swärd, Jens O. Lagerstedt, Olga Göransson, Karin G. Stenkula   +13 more
doaj  

Quantitating the Transfer of the HTLV-1 p8 Protein Between T-Cells by Flow Cytometry

Frontiers in Microbiology, 2018
The Human T-cell leukemia virus type 1 (HTLV-1)-encoded accessory protein p8 is cleaved from the precursor protein p12 encoded by the HTLV-1 open reading frame I. Both p12 and p8 are thought to contribute to efficient viral persistence.
Norbert Donhauser, Stefanie Heym, Andrea K. Thoma-Kress   +2 more
doaj   +1 more source

Molecularly imprinted polymer-based catalytic micromotors for selective protein transport.

Journal of the American Chemical Society, 2013
We demonstrate an attractive nanomachine "capture and transport" target isolation strategy based on molecularly imprinted polymers (MIPs). MIP-based catalytic microtubular engines are prepared by electropolymerization of the outer polymeric layer in the ...
J. Orozco, A. Cortés, Guanzhi Cheng, Sirilak Sattayasamitsathit, W. Gao, Xiaomiao Feng, Yufeng Shen, Joseph Wang   +7 more
semanticscholar   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, EarlyView.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

Cell-Penetrating Peptide-Mediated Biomolecule Transportation in Artificial Lipid Vesicles and Living Cells

Molecules
Signal transduction and homeostasis are regulated by complex protein interactions in the intracellular environment. Therefore, the transportation of impermeable macromolecules (nucleic acids, proteins, and drugs) that control protein interactions is ...
Akari Miwa, Koki Kamiya
doaj   +1 more source

Signal Recognition Particle RNA Contributes to Oxidative Stress Response in Deinococcus radiodurans by Modulating Catalase Localization

Frontiers in Microbiology, 2020
The proper functioning of many proteins requires their transport to the correct cellular compartment or their secretion. Signal recognition particle (SRP) is a major protein transport pathway responsible for the co-translational movement of integral ...
Runhua Han, Jaden Fang, Jessie Jiang, Elena K. Gaidamakova, Elena K. Gaidamakova, Rok Tkavc, Rok Tkavc, Rok Tkavc, Michael J. Daly, Lydia M. Contreras, Lydia M. Contreras   +10 more
doaj   +1 more source