Results 71 to 80 of about 8,268,147 (364)
Applications of PDEs and Stochastic Modeling to Protein Transport in Cell Biology [PDF]
arXiv, 2022 Intracellular transport processes are essential to the healthy development of many organisms as well as more generally to healthy cellular function. The complex dynamics and interactions between protein molecules and filaments on different time and spatial scales generate many opportunities for mathematical modeling and analysis that can provide ...
arxiv
Collective Molecular Dynamics in Proteins and Membranes [PDF]
Biointerphases Volume 3, Issue 2, pp. FB83-FB90 (June 2008), 2008 The understanding of dynamics and functioning of biological membranes and in particular of membrane embedded proteins is one of the most fundamental problems and challenges in modern biology and biophysics. In particular the impact of membrane composition and properties and of structure and dynamics of the surrounding hydration water on protein ...
arxiv +1 more source
Active transport of proteins into the nucleus [PDF]
FEBS Letters, 1990 Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. This transport is highly selective process that can be divided into two steps, receptor‐binding followed by translocation through the nuclear envelope. Receptor‐binding is mediated by nuclear localization signals that have been identified in many nuclear ...
Wagner, P. +3 more
openaire +4 more sources
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA
Science, 2016 Location, location, location Aggregates of certain disease-associated proteins are involved in neurodegeneration. Woerner et al. now show that the exact location of these aggregates in the cell may be the key to their pathology (see the Perspective by Da
Andreas C. Woerner +11 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source
Caudo‐rostral brain spreading of α‐synuclein through vagal connections
EMBO Molecular Medicine, 2013 α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy +6 more
doaj +1 more source
Frontiers in Microbiology, 2018 The pathogenicity locus (PaLoc) of Clostridioides difficile usually comprises five genes (tcdR, tcdB, tcdE, tcdA, tcdC). While the proteins TcdA and TcdB represent the main toxins of this pathogen, TcdR and TcdC are involved in the regulation of their ...
Denise Mehner-Breitfeld +8 more
doaj +1 more source
Direct observation of silver nanoparticle-ubiquitin corona formation [PDF]
, 2012 Upon entering physiological environments, nanoparticles readily assume the form of a nanoparticle-protein corona that dictates their biological identity. Understanding the structure and dynamics of nanoparticle-protein corona is essential for predicting the fate, transport, and toxicity of nanomaterials in living systems and for enabling the vast ...
arxiv +1 more source
CLN3 Loss Disturbs Membrane Microdomain Properties and Protein Transport in Brain Endothelial Cells
Journal of Neuroscience, 2013 Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal childhood-onset neurodegenerative disorder caused by mutations in ceroid lipofuscinosis neuronal-3 (CLN3), a hydrophobic transmembrane protein of unresolved function.
L. Tecedor +5 more
semanticscholar +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source