Results 11 to 20 of about 105,512 (249)

Identification of the tyrosine-protein phosphatase non-receptor type 2 as a rheumatoid arthritis susceptibility locus in europeans.

PLoS ONE, 2013
ObjectivesGenome-wide association studies have facilitated the identification of over 30 susceptibility loci for rheumatoid arthritis (RA). However, evidence for a number of potential susceptibility genes have not so far reached genome-wide significance ...
Joanna E Cobb, Darren Plant, Edward Flynn, Meriem Tadjeddine, Philippe Dieudé, François Cornélis, Lisbeth Ärlestig, Solbritt Rantapää Dahlqvist, George Goulielmos, Dimitrios T Boumpas, Prodromos Sidiropoulos, Sophine B Krintel, Lykke M Ørnbjerg, Merete L Hetland, Lars Klareskog, Thomas Haeupl, Andrew Filer, Christopher D Buckley, Karim Raza, Torsten Witte, Reinhold E Schmidt, Oliver FitzGerald, Douglas Veale, Stephen Eyre, Jane Worthington   +24 more
doaj   +4 more sources

Protein Tyrosine Phosphatase Non-receptor 22 Gene C1858T Polymorphism in Patients with Coexistent Type 2 Diabetes and Hashimoto’s Thyroiditis

Balkan Medical Journal, 2014
Background: A protein tyrosine phosphatase non-receptor type 22 (PTPN22) C1858T gene polymorphism has been reported to be associated with both Type 2 diabetes mellitus (T2DM) and Hashimoto’s thyroiditis (HT) separately.
Funda Bulut, Deniz Erol, Halit Elyas, Fethi Ahmet Özdemir, Halil Doğan, Lezan Keskin   +5 more
doaj   +4 more sources

Enhancing the apo protein tyrosine phosphatase non-receptor type 2 crystal soaking strategy through inhibitor-accessible binding sites. [PDF]

Acta Crystallogr F Struct Biol Commun
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) has recently been recognized as a promising target for cancer immunotherapy. Despite extensive structural and functional studies of other protein tyrosine phosphatases, there is limited structural understanding of PTPN2. Currently, there are only five published PTPN2 structures and none are truly
Bester SM, Linwood R, Kataoka R, Wu WI, Mou TC.   +4 more
europepmc   +3 more sources

Protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene polymorphisms (rs2542151, rs7234029) in Egyptian Behçet's disease patients: a preliminary report. [PDF]

Clin Rheumatol
AbstractSingle nucleotide polymorphisms (SNPs) of the protein tyrosine phosphatase non-receptor type 2 (PTPN2) gene have been documented to be linked with several autoimmune disorders including Behçet’s disease (BD). PTPN2 SNPs rs2542151 and rs7234029 have been assessed using real-time PCR in 96 BD patients and 50 controls matched by age and gender ...
Attia DHS, Alkaffas M, Eissa M, Rashed L, Khattab RAM, Elzanaty R, Khattab RA, Samy LA.   +7 more
europepmc   +3 more sources

Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development [PDF]

Journal of Clinical Investigation, 2021
Protein tyrosine phosphatase non-receptor type 2 (PTPN2) recently emerged as a promising cancer immunotherapy target. We set to investigate the functional role of PTPN2 in the pathogenesis of human colorectal carcinoma (CRC) as its role in immune-silent solid tumors is poorly understood.
Katkeviciute, Egle, Hering, Larissa, Montalban-Arques, Ana, Busenhart, Philipp, Schwarzfischer, Marlene, Manzini, Roberto, Conde, Javier, Atrott, Kirstin, Lang, Silvia, Rogler, Gerhard, Naschberger, Elisabeth, Schellerer, Vera S, Stürzl, Michael, Rickenbacher, Andreas, Turina, Matthias, Weber, Achim, Leibl, Sebastian, Leventhal, Gabriel E, Levesque, Mitchell Paul, Boyman, Onur, Scharl, Michael, Spalinger, Marianne R   +21 more
openaire   +3 more sources

Tyrosine phosphorylation tunes chemical and thermal sensitivity of TRPV2 ion channel

eLife, 2022
Transient receptor potential vanilloid 2 (TRPV2) is a multimodal ion channel implicated in diverse physiopathological processes. Its important involvement in immune responses has been suggested such as in the macrophages’ phagocytosis process.
Xiaoyi Mo, Peiyuan Pang, Yulin Wang, Dexiang Jiang, Mengyu Zhang, Yang Li, Peiyu Wang, Qizhi Geng, Chang Xie, Hai-Ning Du, Bo Zhong, Dongdong Li, Jing Yao   +12 more
doaj   +1 more source

Role of protein tyrosine phosphatase non-receptor type 7 in the regulation of TNF-α production in RAW 264.7 macrophages. [PDF]

PLoS ONE, 2013
Protein tyrosine phosphatases play key roles in a diverse range of cellular processes such as differentiation, cell proliferation, apoptosis, immunological signaling, and cytoskeletal function.
Huiyun Seo, In-Seon Lee, Jae Eun Park, Sung Goo Park, Do Hee Lee, Byoung Chul Park, Sayeon Cho   +6 more
doaj   +1 more source

The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. [PDF]

PLoS ONE, 2015
Contact inhibition of cell movement and proliferation is critical for proper organogenesis and tissue remodeling. We show here a novel regulatory mechanism for this contact inhibition using cultured vascular endothelial cells.
Shota Yamana, Amina Tokiyama, Kiyohito Mizutani, Ken-ichi Hirata, Yoshimi Takai, Yoshiyuki Rikitake   +5 more
doaj   +1 more source

Type 1 Diabetes and Autoimmune Thyroid Disease—The Genetic Link

Frontiers in Endocrinology, 2021
Type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) are the most frequent chronic autoimmune diseases worldwide. Several autoimmune endocrine and non-endocrine disorders tend to occur together.
Lara Frommer, George J. Kahaly
doaj   +1 more source

Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus

Frontiers in Immunology, 2020
Circular RNAs (circRNAs) constitute a class of covalently circular non-coding RNA molecules formed by 5′ and 3′ end back-splicing. The rapid development of bioinformatics and large-scale sequencing has led to the identification of functional circRNAs ...
Lan Yang, Lan Yang, Xiao Han, Xiao Han, Caiyan Zhang, Caiyan Zhang, Chengjun Sun, Saihua Huang, Saihua Huang, Wenfeng Xiao, Wenfeng Xiao, Yajing Gao, Yajing Gao, Qiuyan Liang, Qiuyan Liang, Feihong Luo, Wei Lu, Jinrong Fu, Yufeng Zhou, Yufeng Zhou   +19 more
doaj   +1 more source