Results 21 to 30 of about 105,512 (249)
PTK2 and PTPN11 expression in myelodysplastic syndromes
Clinics, 2013 OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini +6 more
doaj +1 more source
BAR Proteins PSTPIP1/2 Regulate Podosome Dynamics and the Resorption Activity of Osteoclasts. [PDF]
PLoS ONE, 2016 Bone resorption in vertebrates relies on the ability of osteoclasts to assemble F-actin-rich podosomes that condense into podosomal belts, forming sealing zones.
Martin Sztacho +5 more
doaj +1 more source
Virulence, 2021 Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf +5 more
doaj +1 more source
Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. [PDF]
PLoS ONE, 2013 Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV
Sabarinathan Ramachandran +6 more
doaj +1 more source
Frontiers in Cellular and Infection Microbiology, 2015 Genome wide association studies have identified several genes that might be associated with increase susceptibility to Type 1 Diabetes (T1D) and Crohn’s disease.
Muna eAbdulrahim +3 more
doaj +1 more source
Frontiers in Pharmacology, 2023 Introduction: The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown adipose tissue, which is involved in the dissipation of energy via heat expenditure
Yapeng Liu +9 more
doaj +1 more source
PTPN2 as a promoter of colon carcinoma via reduction of inflammasome activation
Molecular & Cellular Oncology, 2018 We have recently demonstrated that macrophage-specific loss of Protein tyrosine phosphatase non-receptor type 2 (PTPN2) promotes inflammasome activation, resulting in protection from colorectal cancer.
Marianne R. Spalinger, Michael Scharl
doaj +1 more source
PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells
Cell Reports, 2020 Summary: Manipulating molecules that impact T cell receptor (TCR) or cytokine signaling, such as the protein tyrosine phosphatase non-receptor type 2 (PTPN2), has significant potential for advancing T cell-based immunotherapies.
Markus Flosbach +13 more
doaj +1 more source
Tyrosine‐protein phosphatase non‐receptor type 2 inhibits alveolar bone resorption in diabetic periodontitis via dephosphorylating CSF1 receptor [PDF]
Journal of Cellular and Molecular Medicine, 2019 Abstract Tyrosine‐protein phosphatase non‐receptor type 2 (PTPN2) is an important protection factor for diabetes and periodontitis, but the underlying mechanism remains elusive. This study aimed to identify the substrate of PTPN2 in mediating beneficial effects of 25‐Hydroxyvitamin D 3
Dongjiao Zhang +6 more
openaire +2 more sources
Cells, 2019 This study was aimed to investigate the role of SHP2 (Src-homology-2-containing phosphotyrosine phosphatase) in intricate signaling networks invoked by bovine oocyte to achieve maturation and blastocyst development.
Muhammad Idrees +8 more
doaj +1 more source