Results 171 to 180 of about 277,071 (303)

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Protein tyrosine phosphatase PTP1B is a positive regulator of the intracellular development of <i>Chlamydia trachomatis</i>. [PDF]

Infect Immun
Khan MS, Peles R, Haralampiev A, Becerra N, Jewett TJ.   +4 more
europepmc   +1 more source

Protein-tyrosine Phosphatase ϵ [PDF]

Journal of Biological Chemistry, 1995
Ari Elson, Philip Leder
openaire   +1 more source

The β integrin modulates serotonin sensitivity via NPxY motifs to regulate egg laying and mechanosensation behaviors in Caenorhabditis elegans

Developmental Dynamics, EarlyView.
Abstract Background Integrin is an αβ heterodimeric receptor to the extracellular matrix; its binding to the matrix recruits focal adhesions to two NPxY motifs, the tyrosine phosphorylation sites in the cytoplasmic domain. Studies found that replacing tyrosines (Y) with phenylalanines (F) in the motif of β1 integrin displayed little developmental or ...
Josh Haram Bumm, Daniel Dogeon Lee, Zhongqiang Qiu, Angela Haeun Choi, Meghana Kolluri, Michael J. Olsen, Lianzijun Wang, Myeongwoo Lee   +7 more
wiley   +1 more source

Expression of low molecular weight protein tyrosine phosphatase in gastric cancer and its association with clinical outcomes and oncogenic hallmarks. [PDF]

Mol Med
Xiang L, Zhou Y, Li S, Smits R, Yu J, Peppelenbosch MP, Fuhler GM.   +6 more
europepmc   +1 more source

Protein Tyrosine Phosphatase 1B [PDF]

Developmental Cell, 2002
Cook, W.S., Unger, R.H.
openaire   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

Targeting Protein Tyrosine Phosphatase 1B (PTP1B) to Improve Insulin Sensitivity Using Indole-Fused Glycyrrhetinic Acid Conjugates with Amino Acids. [PDF]

ACS Med Chem Lett
De-la-Cruz-Martínez L, Equihua-González D, Torres-Chacón DL, Ortiz-Barragán E, Torres-Valencia JM, Martínez-Casares RM, Pérez-Villanueva J, González-Andrade M, Almanza-Pérez JC, Cortés-Benítez F.   +9 more
europepmc   +1 more source

Inherited metabolic epilepsies–established diseases, new approaches

Epilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B. [PDF]

Infect Immun
Raunak R, Bahl A, Srivastava S, Rakshit R, Bansal S, Kant S, Mandal CC, Pandey S, Tripathi D.   +8 more
europepmc   +1 more source