Results 181 to 190 of about 3,688,591 (305)

Conformational Dynamics and Catalytic Backups in a Hyper-thermostable Engineered Archaeal Protein Tyrosine Phosphatase. [PDF]

JACS Au
Yehorova D, Alansson N, Shen R, Denson JM, Robinson M, Risso VA, Ramirez Molina N, Loria JP, Gaucher EA, Sanchez-Ruiz JM, Hengge AC, Johnson SJ, Kamerlin SCL.   +12 more
europepmc   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites. [PDF]

J Biol Chem
Perdikari A, Woods VA, Ebrahim A, Lawler K, Bounds R, Shah DS, Singh NI, Mehlman TS, Riley BT, Sharma S, Morris JW, Keogh JM, Henning E, Smith M, Farooqi IS, Keedy DA.   +15 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Lack of striatal-enriched protein tyrosine phosphatase affected the serotonin system, behavior, and brain morphology in mice. [PDF]

Front Psychiatry
Moskaliuk V, Komleva P, Khotskin N, Arefieva A, Shevelev O, Korablev A, Serova I, Battulin N, Kulikov A, Naumenko V, Bazovkina D, Kulikova E.   +11 more
europepmc   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Protein tyrosine phosphatase PTP1B is a positive regulator of the intracellular development of <i>Chlamydia trachomatis</i>. [PDF]

Infect Immun
Khan MS, Peles R, Haralampiev A, Becerra N, Jewett TJ.   +4 more
europepmc   +1 more source

Protein Tyrosine Phosphatase [PDF]

, 2020
openaire   +1 more source

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges

Neuroprotection, EarlyView.
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ramin Goudarzi, Saman Khosravi, Ahmad Reza Dehpour   +5 more
wiley   +1 more source

Activity-Guided Isolation of <i>sn</i>-1,3-Dipalmitoyl-2-oleoylglycerol as Protein Tyrosine Phosphatase 1B and α-Glucosidase Inhibitor from Skipjack Tuna (<i>Katsuwonus pelamis</i>). [PDF]

Int J Mol Sci
Ali MY, Kim DH, Jung HJ, Nam TJ, Choi JS.   +4 more
europepmc   +1 more source