Results 201 to 210 of about 3,688,591 (305)

Identification of novel pyrazolo[4,3-c]pyridine and diazepane derivatives as potent inhibitors of <i>Mycobacterium tuberculosis</i> protein tyrosine phosphatase B. [PDF]

Infect Immun
Raunak R, Bahl A, Srivastava S, Rakshit R, Bansal S, Kant S, Mandal CC, Pandey S, Tripathi D.   +8 more
europepmc   +1 more source

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Galloylated Phenolics from Indian Gooseberry (<i>Phyllanthus emblica</i> L.) and Their Protein Tyrosine Phosphatase 1B (PTP1B) Inhibition. [PDF]

ACS Omega
Cao TQ, Kwon S, Park YM, Kim JS, Son JE, Tuong LT, Hahn D.   +6 more
europepmc   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

[Corrigendum] Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors. [PDF]

Int J Oncol
Sun PH, Chen G, Mason M, Jiang WG, Ye L.
europepmc   +1 more source

Identification and Discrimination of Sulfated and Unsulfated Gut‐Hormone Biomarkers in Human Serum by Nanopore

Small, EarlyView.
This study discriminates between sulfated and unsulfated cholecystokinin‐8 gut‐hormone forms at single‐molecule‐level resolution. Using an aerolysin nanopore embedded in a hybrid lipid‐polymer membrane, the system produces distinct electrical signatures enabling highly sensitive detection, even in 20% human serum.
Luca Iesu, Laurent Bacri, Juan Pelta, Benjamin Cressiot   +3 more
wiley   +1 more source

Chronic inhibition of receptor protein tyrosine phosphatase β/ζ reduces amyloid plaque load and modulates pleiotrophin-expressing glial cells, glial-plaque interactions and genes related to amyloid beta clearance. [PDF]

Front Pharmacol
Fontán-Baselga T, Cañeque-Rufo H, Rivera-Illades E, Gramage E, Zapico JM, de Pascual-Teresa B, Ramos-Álvarez MDP, Vicente-Rodríguez M, Herradón G.   +8 more
europepmc   +1 more source

A Triangulenum‐Based Biosensor Platform for Mapping Kinase Activity in T Cells

Small, EarlyView.
Novel peptide biosensors based on long‐lifetime triangulenium dyes are developed for the real‐time, non‐invasive mapping of Akt1 and Src kinase activities in living cells. Utilizing FLIM microscopy, these highly specific, biocompatible probes overcome cellular autofluorescence.
Carmen Salto‐Giron, Angélica Martín‐Priego, Francisco Fueyo‐González, María Mar Quesada‐Moreno, Federico Movilla, Antonio Reinoso, Laura Espinar‐Barranco, Rafael Salto, Amparo Navarro, Miguel Fribourg, Angel Orte, Juan A. González‐Vera   +11 more
wiley   +1 more source

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host. [PDF]

Aging Cancer
Wang Z, Liu Y, Yang J, Hilliard TS, Safavi-Sohi R, Hu DD, Harper EI, Dominique G, Wang W, Johnson J, Asem M, Milosevich W, Carlson JF, Bai Y, Miao J, Zhang ZY, Champion MM, Sharon Stack M.   +17 more
europepmc   +1 more source