Results 111 to 120 of about 41,275 (256)

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Methyl Syringate Stimulates Glucose Uptake by Inhibiting Protein Tyrosine Phosphatases Relevant to Insulin Resistance. [PDF]

Life (Basel), 2023
Ahn D, Kwon J, Song S, Lee J, Yoon S, Chung SJ.   +5 more
europepmc   +1 more source

Combining phenotypic, physiological, and multi‐omics studies to provide new insights on the role of 2,4‐epibrassinolide in regulation of seed shattering in Elymus sibiricus L.

Grassland Research, EarlyView.
Abstract Background Seed shattering limits the production of Elymus sibiricus L., and application of exogenous brassinosteroid significantly alleviates plant organ abscission. Methods To explore the potential regulatory network of brassinosteroid on seed shattering, the abscission zone of E. sibiricus cv. Lanyu No.
Huanhuan Lu, Yiyang Wan, Liuban Tang, Yongsen Qiu, Yancui Zhao, Yuying Zheng, Wengang Xie   +6 more
wiley   +1 more source

Synthesis of small peptide compounds, molecular docking, and inhibitory activity evaluation against phosphatases PTP1B and SHP2

Drug Design, Development and Therapy, 2018
Tomasz Kostrzewa,1 Kamlesh K Sahu,2 Magdalena Gorska-Ponikowska,1 Jack A Tuszynski,3 Alicja Kuban-Jankowska1 1Department of Medical Chemistry, Medical University of Gdansk, Gdansk, Poland; 2Department of Medical Microbiology and Immunology, University ...
Kostrzewa T, Sahu KK, Gorska-Ponikowska M, Tuszynski JA, Kuban-Jankowska A   +4 more
doaj  

Correction to "Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases". [PDF]

J Am Chem Soc, 2022
Crean RM, Biler M, Corbella M, Calixto AR, van der Kamp MW, Hengge AC, Kamerlin SCL.   +6 more
europepmc   +1 more source

Protein Tyrosine Phosphatases: Mechanisms in Cancer. [PDF]

Int J Mol Sci, 2021
Sivaganesh V, Sivaganesh V, Scanlon C, Iskander A, Maher S, Lê T, Peethambaran B.   +6 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Functional interrogation and therapeutic targeting of protein tyrosine phosphatases. [PDF]

Biochem Soc Trans, 2021
Krabill AD, Zhang ZY.
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Unsaturated Phosphorus Electrophiles to Probe Protein Tyrosine Phosphatases. [PDF]

Angew Chem Int Ed Engl
Poulou E, Ruwolt M, Stieger CE, Kemnitz-Hassanin K, Hackenberger CPR.   +4 more
europepmc   +1 more source