Results 1 to 10 of about 277,071 (303)

The Protein Tyrosine Phosphatase 1B Modulates the Activation of Yes-Associated Protein and Sensitizes to Cytotoxic Chemotherapy in Preclinical Models of Cholangiocarcinoma [PDF]

Cells
Lacking effective therapeutics, cholangiocarcinoma (CCA) remains a deadly malignancy of the biliary tract. The Hippo pathway effector protein Yes-associated protein (YAP) is implicated in CCA pathogenesis and chemotherapeutic resistance; however, the ...
Ryan D. Watkins, Jennifer L. Tomlinson, EeeLN H. Buckarma, Hendrien Kuipers, Danielle M. Carlson, Nathan W. Werneburg, Daniel R. O’Brien, Chen Wang, Rory L. Smoot   +8 more
doaj   +2 more sources

Research progress on protein tyrosine phosphatase A from Mycobacterium tuberculosis [PDF]

Frontiers in Immunology
Mycobacterium tuberculosis (Mtb) protein tyrosine phosphatase A (PtpA) is a crucial tyrosine phosphatase involved in the pathogenesis of tuberculosis.
Yifei Cai, Yifei Cai, Leiliang Zhang, Leiliang Zhang   +3 more
doaj   +2 more sources

Protein tyrosine phosphatase delta is a STAT3-phosphatase and suppressor of metabolic liver disease [PDF]

eGastroenterology
Objective Impaired hepatic expression of protein tyrosine phosphatase delta (PTPRD) is associated with increased STAT3 transcriptional activity and reduced survival from hepatocellular carcinoma in patients with chronic hepatitis C virus infection ...
Thomas F Baumert, Charlotte Bach, Patrick Pessaux, Catherine Schuster, Frank Jühling, Sarah C Durand, Yujin Hoshida, Fabien Zoulim, Atish Mukherji, Naoto Fujiwara, Marine A Oudot, Armando Andres Roca Suarez, Michel L Tremblay, Barbara Testoni, Joachim Lupberger, Romain Parent, Laurent Mailly, Nassim Dali-Youcef, Emanuele Felli, Maria Saez-Palma, Julien Moehlin, Alessia Virzì, Nicolas Brignon, Eugenie Schaeffer, Romain Martin, Laura Meiss-Heydmann, Zakaria Boulahtouf, Lea Girard, Emma Osswald, Carole Jamey, Daniel Brumaru, Bhuvaneswari Koneru   +31 more
doaj   +2 more sources

New natural protein tyrosine phosphatase 1B inhibitors from Gynostemma pentaphyllum [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease mainly caused by insulin resistance, which can lead to a series of complications such as cardiovascular disease, retinopathy, and its typical clinical symptom is hyperglycaemia.
Xianting Wang, Yidan Deng, Jianmei Wang, Lin Qin, Yimei Du, Qianru Zhang, Di Wu, Xingdong Wu, Jian Xie, Yuqi He, Daopeng Tan   +10 more
doaj   +2 more sources

Protein Tyrosine Phosphatase PRL-3: A Key Player in Cancer Signaling [PDF]

Biomolecules
Protein phosphatases are primarily responsible for dephosphorylation modification within signal transduction pathways. Phosphatase of regenerating liver-3 (PRL-3) is a dual-specific phosphatase implicated in cancer pathogenesis.
Haidong Liu, Xiao Li, Yin Shi, Zu Ye, Xiangdong Cheng   +4 more
doaj   +2 more sources

Protein Tyrosine Phosphatase Biochemical Inhibition Assays

Bio-Protocol, 2022
Disturbance of the dynamic balance between protein tyrosine phosphorylation and dephosphorylation, modulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs), is known to be crucial for the development of many human ...
Marek Baranowski, Jiaqian Wu, Ye Na Han, Lester Lambert, Nicholas Cosford, Lutz Tautz   +5 more
doaj   +1 more source

The Role of DmCatD, a Cathepsin D-Like Peptidase, and Acid Phosphatase in the Process of Follicular Atresia in Dipetalogaster maxima (Hemiptera: Reduviidae), a Vector of Chagas' Disease [PDF]

, 2015
In this work, we have investigated the involvement of DmCatD, a cathepsin D-like peptidase, and acid phosphatase in the process of follicular atresia of Dipetalogaster maxima, a hematophagous insect vector of Chagas' disease. For the studies, fat bodies,
Canavoso, Lilian Etelvina, Fruttero, Leonardo Luis, Leyria, Jimena, Nazar, Magalí   +3 more
core   +13 more sources

T Cell Protein Tyrosine Phosphatase in Osteoimmunology

Frontiers in Immunology, 2021
Osteoimmunology highlights the two-way communication between bone and immune cells. T cell protein tyrosine phosphatase (TCPTP), also known as protein-tyrosine phosphatase non-receptor 2 (PTPN2), is an intracellular protein tyrosine phosphatase (PTP ...
Ya-nan Wang, Ya-nan Wang, Ya-nan Wang, Shiyue Liu, Shiyue Liu, Shiyue Liu, Tingting Jia, Tingting Jia, Tingting Jia, Yao Feng, Yao Feng, Yao Feng, Wenjing Zhang, Wenjing Zhang, Wenjing Zhang, Xin Xu, Xin Xu, Xin Xu, Dongjiao Zhang, Dongjiao Zhang, Dongjiao Zhang   +20 more
doaj   +1 more source

HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. [PDF]

PLoS ONE, 2009
The HD-PTP protein has been described as a tumor suppressor candidate and based on its amino acid sequence, categorized as a classical non-transmembrane protein tyrosine phosphatase (PTP).
Marie-Claude Gingras, Yu Ling Zhang, Dmitri Kharitidi, Alastair J Barr, Stefan Knapp, Michel L Tremblay, Arnim Pause   +6 more
doaj   +1 more source

T Cell Protein Tyrosine Phosphatase in Glucose Metabolism

Frontiers in Cell and Developmental Biology, 2021
T cell protein tyrosine phosphatase (TCPTP), a vital regulator in glucose metabolism, inflammatory responses, and tumor processes, is increasingly considered a promising target for disease treatments and illness control.
Ya-nan Wang, Ya-nan Wang, Ya-nan Wang, Shiyue Liu, Shiyue Liu, Shiyue Liu, Tingting Jia, Tingting Jia, Tingting Jia, Yao Feng, Yao Feng, Yao Feng, Xin Xu, Xin Xu, Xin Xu, Dongjiao Zhang, Dongjiao Zhang, Dongjiao Zhang   +17 more
doaj   +1 more source