A Polydnavirus Protein Tyrosine Phosphatase Negatively Regulates the Host Phenoloxidase Pathway
Viruses, 2022 Polydnavirus (PDV) is a parasitic factor of endoparasitic wasps and contributes greatly to overcoming the immune response of parasitized hosts.
Hong-Shuai Gao +7 more
doaj +1 more source
Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling
Life Science Alliance, 2021 This study analyses the function of the protein tyrosine phosphatase 1B identifying its binding partners and dephosphorylation targets for modulating B cell antigen receptor signaling.
Jennifer J Schwarz +8 more
doaj +1 more source
Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
Frontiers in Immunology, 2021 The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response.
Feiling Xie +7 more
doaj +1 more source
Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy.
PLoS ONE, 2021 Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical stress.
Carolina Fernández +10 more
doaj +1 more source
PTK2 and PTPN11 expression in myelodysplastic syndromes
Clinics, 2013 OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini +6 more
doaj +1 more source
Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis
Haematologica, 2020 There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer +5 more
doaj +1 more source
Protein tyrosine phosphatase TbPTP1:A molecular switch controlling life cycle differentiation in trypanosomes [PDF]
, 2006 Differentiation in African trypanosomes (Trypanosoma brucei) entails passage between a mammalian host, where parasites exist as a proliferative slender form or a G0-arrested stumpy form, and the tsetse fly.
Szoor, Balazs; id_orcid +12 more
core +1 more source
Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Marine Drugs, 2006 : Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against
Jun'ichi Kobayashi +7 more
doaj +1 more source
The TriTryp Phosphatome: analysis of the protein phosphatase catalytic domains [PDF]
, 2007 Background The genomes of the three parasitic protozoa Trypanosoma cruzi, Trypanosoma brucei and Leishmania major are the main subject of this study. These parasites are responsible for devastating human diseases known as Chagas disease, African sleeping
Szoor, Balazs; id_orcid +26 more
core +1 more source
Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2 [PDF]
, 2002 Receptor tyrosine kinases (RTKs) play distinct roles in multiple biological systems. Many RTKs transmit similar signals, raising questions about how specificity is achieved.
Zhang, S. +13 more
core +1 more source