Frontiers in Pharmacology, 2023 Tyrosine-protein phosphatase non-receptor type 2(PTPN2), an important member of the protein tyrosine phosphatase family, can regulate various signaling pathways and biological processes by dephosphorylating receptor protein tyrosine kinases. Accumulating
Xiao-Er Tang +2 more
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Off-target effects of protein tyrosine phosphatase inhibitors on oncostatin M-treated human epidermal keratinocytes: the phosphatase targeting STAT1 remains unknown [PDF]
PeerJ, 2020 Cytokine signaling in the epidermis has an important role in maintaining barrier function and is perturbed in pathological conditions. Environmental exposures, such as to metal compounds, are of interest for their potential contribution to skin disease ...
Brian V. Hong, Ji H. Lee, Robert H. Rice
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A Polydnavirus Protein Tyrosine Phosphatase Negatively Regulates the Host Phenoloxidase Pathway
Viruses, 2022 Polydnavirus (PDV) is a parasitic factor of endoparasitic wasps and contributes greatly to overcoming the immune response of parasitized hosts.
Hong-Shuai Gao +7 more
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Quantitative proteomics identifies PTP1B as modulator of B cell antigen receptor signaling
Life Science Alliance, 2021 This study analyses the function of the protein tyrosine phosphatase 1B identifying its binding partners and dephosphorylation targets for modulating B cell antigen receptor signaling.
Jennifer J Schwarz +8 more
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Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase [PDF]
Biochemical Journal, 1995 We have isolated the murine cDNA homologue of the human protein tyrosine phosphatase PTP-PEST (MPTP-PEST) from an 18.5-day mouse embryonic kidney library. The cDNA isolated has a single open reading frame predicting a protein of 775 amino acids. When expressed in vitro as a glutathione S-transferase fusion protein, the catalytic domain (residues 1-453)
Charest, Alain +3 more
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Regulatory Functions of Protein Tyrosine Phosphatase Receptor Type O in Immune Cells
Frontiers in Immunology, 2021 The members of the protein tyrosine phosphatase (PTP) family are key regulators in multiple signal transduction pathways and therefore they play important roles in many cellular processes, including immune response.
Feiling Xie +7 more
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Polycystin-1 is required for insulin-like growth factor 1-induced cardiomyocyte hypertrophy.
PLoS ONE, 2021 Cardiac hypertrophy is the result of responses to various physiological or pathological stimuli. Recently, we showed that polycystin-1 participates in cardiomyocyte hypertrophy elicited by pressure overload and mechanical stress.
Carolina Fernández +10 more
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PTK2 and PTPN11 expression in myelodysplastic syndromes
Clinics, 2013 OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein ...
Mariana Lazarini +6 more
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A new monoclonal antibody detects downregulation of protein tyrosine phosphatase receptor type γ in chronic myeloid leukemia patients [PDF]
, 2017 Background: Protein tyrosine phosphatase receptor gamma (PTPRG) is a ubiquitously expressed member of the protein tyrosine phosphatase family known to act as a tumor suppressor gene in many different neoplasms with mechanisms of inactivation including ...
Al Sayab, Ali +15 more
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Manzamenones Inhibit T-Cell Protein Tyrosine Phosphatase
Marine Drugs, 2006 : Manzamenones A~C (1~3) and E~F (5~6), unique oxylipin metabolites isolated from a marine sponge Plakortis sp., have been found to exhibit inhibitory activity against Tcell protein tyrosine phosphatase (TCPTP). The inhibitory activity of 2 and 5 against
Jun'ichi Kobayashi +7 more
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