Results 31 to 40 of about 277,071 (303)

Protein Tyrosine Phosphatase Assays [PDF]

Current Protocols in Immunology, 2011
AbstractTyrosine phosphorylation and dephosphorylation of proteins play a critical role in many processes of the immune system, from early development to fully differentiated effector function. Since the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs) determine the steady‐state level of tyrosine ...
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Serum levels of RBP4 and adipose tissue levels of PTP1B are increased in obese men resident in northeast Scotland without associated changes in ER stress response genes [PDF]

, 2012
Peer reviewedPublisher ...
Agouni, Abdelali, Delibegovic, Mirela, Hoggard, Nigel, Mody, Nimesh   +3 more
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Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2

Frontiers in Cell and Developmental Biology, 2022
Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is indispensable during embryonic development.
Maja Solman, Daniëlle T. J. Woutersen, Jeroen den Hertog, Jeroen den Hertog   +3 more
doaj   +1 more source

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4

Journal of Lipid Research, 2011
Acyl-CoA synthetase 4 (ACSL4) is implicated in fatty acid metabolism with marked preference for arachidonic acid (AA). ACSL4 plays crucial roles in physiological functions such as steroid synthesis and in pathological processes such as tumorigenesis ...
Mariana Cooke, Ulises Orlando, Paula Maloberti, Ernesto J. Podestá, Fabiana Cornejo Maciel   +4 more
doaj   +1 more source

The Protein Tyrosine Phosphatase Receptor Delta Regulates Developmental Neurogenesis

Cell Reports, 2020
Summary: PTPRD is a receptor protein tyrosine phosphatase that is genetically associated with neurodevelopmental disorders. Here, we asked whether Ptprd mutations cause aberrant neural development by perturbing neurogenesis in the murine cortex.
Hideaki Tomita, Francisca Cornejo, Begoña Aranda-Pino, Cameron L. Woodard, Constanza C. Rioseco, Benjamin G. Neel, Alejandra R. Alvarez, David R. Kaplan, Freda D. Miller, Gonzalo I. Cancino   +9 more
doaj   +1 more source

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy. [PDF]

, 2015
The low molecular weight protein tyrosine phosphatase (LMPTP), encoded by the ACP1 gene, is a ubiquitously expressed phosphatase whose in vivo function in the heart and in cardiac diseases remains unknown.
Al-Habeeb, Waleed, Al-Haffar, Kamar Mohamed Adib, Al-Mohanna, Falah, Alvarez, Roberto, Assiri, Abdullah, Awad, Salma Mahmoud, Belhaj, Karim, Bottini, Nunzio, Colak, Dilek, Jordan, Maria C, Kunhi, Muhammad, Liu, Yingge, Marashly, Qussay, Poizat, Coralie, Quijada, Pearl, Roos, Kenneth P, Stanford, Stephanie M, Sussman, Mark, Toko, Haruhiro, Wade, Fallou, Zahid, Israa   +20 more
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NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]

, 2018
Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana, Besharat, ZEIN MERSINI, Capalbo, Carlo, Checquolo, Saula, D'Amati, Giulia, Del Gaudio, Francesca, Diluvio, Giulia, Franciosa, Giulia, Giuli, MARIA VALERIA, Giuliani, Eugenia, Maroder, Marella, Palermo, Rocco, Pignataro, MARIA GEMMA, Talora, Claudio, Vacca, Alessandra   +14 more
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Scaffold Role of DUSP22 in ASK1-MKK7-JNK Signaling Pathway. [PDF]

PLoS ONE, 2016
Mitogen-activated protein kinases (MAPKs) are involved in a variety of intracellular events such as gene expression, cell proliferation, and programmed cell death.
Anna Ju, Young-Chang Cho, Ba Reum Kim, Sung Goo Park, Jeong-Hoon Kim, Kwonseop Kim, Jaehwi Lee, Byoung Chul Park, Sayeon Cho   +8 more
doaj   +1 more source

Minimally disruptive optical control of protein tyrosine phosphatase 1B

Nature Communications, 2020
Protein tyrosine phosphatases regulate many cellular processes but are difficult to study in their native context. Here the authors develop an approach for using light to control the activity of a disease-relevant phosphatase without interfering with its
Akarawin Hongdusit, Peter H. Zwart, Banumathi Sankaran, Jerome M. Fox   +3 more
doaj   +1 more source

Protein tyrosine phosphatases: regulatory mechanisms [PDF]

The FEBS Journal, 2008
Protein‐tyrosine phosphatases are tightly controlled by various mechanisms, ranging from differential expression in specific cell types to restricted subcellular localization, limited proteolysis, post‐translational modifications affecting intrinsic catalytic activity, ligand binding and dimerization.
den Hertog, J., Ostman, A., Bohmer, F.D.
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