Results 21 to 30 of about 3,688,591 (305)

Efecto inhibidor del extracto acuoso de hojas de Persea americana Mill y sus fracciones sobre PTP1B como diana terapéutica para la diabetes tipo 2 [PDF]

, 2014
Persea Americana Mill (Lauraceae), is a popular plant in Cuba due to its nutritional and medicinal properties. The fruit of the plant is commonly known as avocado.
Harvey, Alan, Sánchez-Calero, Janet, Marrero-Faz, Evangelina, Young, Louise   +3 more
core   +3 more sources

Protein kinase C-dependent dephosphorylation of tyrosine hydroxylase requires the B56δ heterotrimeric form of protein phosphatase 2A. [PDF]

PLoS ONE, 2011
Tyrosine hydroxylase, which plays a critical role in regulation of dopamine synthesis, is known to be controlled by phosphorylation at several critical sites.
Jung-Hyuck Ahn, Yong Kim, Hee-Sun Kim, Paul Greengard, Angus C Nairn   +4 more
doaj   +1 more source

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Molecules, 2023
Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1), a non-receptor member of the protein tyrosine phosphatase (PTP) family, negatively regulates several signaling pathways that are responsible for pathological cell processes in ...
Huiqing Chen, Zekun Liu, Lixin Gao, Li-Fang Yu, Yubo Zhou, Jie Tang, Jia Li, Fan Yang   +7 more
doaj   +1 more source

Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity

mBio, 2019
Protein-tyrosine phosphorylation in bacteria plays a significant role in multiple cellular functions, including those related to community development and virulence.
Young-Jung Jung, Daniel P. Miller, John D. Perpich, Zackary R. Fitzsimonds, Daonan Shen, Jun Ohshima, Richard J. Lamont   +6 more
doaj   +1 more source

Protein tyrosine phosphatases and signalling [PDF]

Journal of Endocrinology, 2005
A cornerstone of many cell-signalling events rests on reversible phosphorylation of tyrosine residues on proteins. The reversibility relies on the coordinated actions of protein tyrosine kinases and protein tyrosine phosphatases (PTPs), both of which exist as large protein families. This review focuses on the rapidly evolving field of the PTPs.
openaire   +2 more sources

Murine protein tyrosine phosphatase-PEST, a stable cytosolic protein tyrosine phosphatase [PDF]

Biochemical Journal, 1995
We have isolated the murine cDNA homologue of the human protein tyrosine phosphatase PTP-PEST (MPTP-PEST) from an 18.5-day mouse embryonic kidney library. The cDNA isolated has a single open reading frame predicting a protein of 775 amino acids. When expressed in vitro as a glutathione S-transferase fusion protein, the catalytic domain (residues 1-453)
Charest, Alain, Wagner, John, Shen, Shi-Hsiang, Tremblay, Michael L.   +3 more
openaire   +3 more sources

Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo [PDF]

, 2007
Endothelial cell survival is indispensable to maintain endothelial integrity and initiate new vessel formation. We investigated the role of SHP-2 in endothelial cell survival and angiogenesis in vitro as well as in vivo.
Groesser, Leopold, Walzog, Barbara, Gloe, Torsten, Sohn, Hae-Young, Krötz, Florian, Plank, Christian, Pohl, Ulrich, Hellwig, Nicole, Mannell, Hanna, Mannell, Hanna;Hellwig, Nicole;Gloe, Torsten;Plank, Christian;Sohn, Hae-Young;Groesser, Leopold;Walzog, Barbara;Pohl, Ulrich;Krötz, Florian, Mannell, H;Hellwig, N;Gloe, T;Plank, C;Sohn, HY;Groesser, L;Walzog, B;Pohl, U;Krötz, F   +10 more
core   +1 more source

Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis [PDF]

, 2012
Peer ...
Welch, A, Robert Judson (279511), Mirela Delibegović, Louise Grant (181930), Grant Louise, Emma K Lees, Judson, R, Andy Welch (181948), Göransson, Olga, Goransson, O, Barbara B Kahn, George D. Mcilroy (181939), Carl Owen (181917), Mcilroy George D., Kendra K. Bence (149032), Olga Göransson, Mody Nimesh, Benjamin G. Neel (162598), Lees, Emma K, Kahn Barbara B., Louise Grant, Nimesh Mody (181963), Bence, Kendra K., Neel Benjamin G., Bence, KK, Grant, L, Owen, C, Mody, Nimesh, Mcilroy, George D, Neel, BG, Owen, Carl, Welch Andy, Olga Göransson (181943), Agouni, Abdelali, Neel, Benjamin G, Abdelali Agouni, Czopek Alicja, Kahn, Barbara B, Neel, Benjamin G., Bence Kendra K., Agouni, A, Lees, Emma K., McIlroy, George, Bence, Kendra K, Abdelali Agouni (181926), Nimesh Mody, Göransson Olga, Lund University., Judson, Robert, Czopek, Alicja, Mody, N, Czopek, A, Kendra K Bence, Mirela Delibegović (181968), Andy Welch, George D Mcilroy, Alicja Czopek (181921), Grant, Louise, Lees, EK, Benjamin G. Neel, Barbara B. Kahn, Delibegovic, Mirela, Barbara B. Kahn (181955), Agouni Abdelali, Kahn, Barbara B., Judson Robert, Göransson, Olga,, Mcilroy, GD, Welch, Andy, Emma K. Lees (181936), Lees Emma K., Robert Judson, Benjamin G Neel, Delibegovic, M, Kendra K. Bence, Delibegović Mirela, Carl Owen, Owen Carl, Mcilroy, George D., Emma K. Lees, Alicja Czopek, Kahn, BB, George D. Mcilroy, Mcilory, GD   +83 more
core   +2 more sources

Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2

Frontiers in Cell and Developmental Biology, 2022
Src homology region 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2) is a highly conserved protein tyrosine phosphatase (PTP), which is encoded by PTPN11 and is indispensable during embryonic development.
Maja Solman, Daniëlle T. J. Woutersen, Jeroen den Hertog, Jeroen den Hertog   +3 more
doaj   +1 more source

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4

Journal of Lipid Research, 2011
Acyl-CoA synthetase 4 (ACSL4) is implicated in fatty acid metabolism with marked preference for arachidonic acid (AA). ACSL4 plays crucial roles in physiological functions such as steroid synthesis and in pathological processes such as tumorigenesis ...
Mariana Cooke, Ulises Orlando, Paula Maloberti, Ernesto J. Podestá, Fabiana Cornejo Maciel   +4 more
doaj   +1 more source