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Protozoan protein tyrosine phosphatases
International Journal for Parasitology, 2008The aim of this review is to provide a synthesis of the published experimental data on protein tyrosine phosphatases from parasitic protozoa, in silico analysis based on the availability of completed genomes and to place available data for individual phosphatases from different unicellular parasites into the comparative and evolutionary context.
Alexandra V, Andreeva +1 more
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Drosophila protein tyrosine phosphatases
Seminars in Cell Biology, 1993Seven protein tyrosine phosphatase (PTPase) genes have been identified in the fruit-fly Drosophila melanogaster. Four of these genes encode receptor-linked PTPases (R-PTPs) that are expressed on central nervous system axons in the embryo. Each axonal R-PTP has an extracellular domain that is homologous to vertebrate adhesion molecules and to identified
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Protein Tyrosine Phosphatases in Autoimmunity
Annual Review of Immunology, 2008Protein tyrosine phosphatases (PTPs) are important regulators of many cellular functions and a growing number of PTPs have been implicated in human disease conditions, such as developmental defects, neoplastic disorders, and immunodeficiency. Here, we review the involvement of PTPs in human autoimmunity. The leading examples include the allelic variant
Torkel, Vang +5 more
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Protein tyrosine phosphatase: enzymatic assays
Methods, 2005Activity assays for tyrosine phosphatases are based on the hydrolysis of a arylphosphate moiety from a synthetic substrate yielding a spectroscopically active product. Many different substrates can be used for these assays with p-nitrophenyl phosphate (pNPP), fluorescein diphosphate (FDP), and 6,8-difluoro-4-methylumbellyferyl phosphate (DiFMUP) being ...
Jacqueline, Montalibet +2 more
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1996
Protein tyrosine phosphorylation and dephosphorylation are believed to be key regulatory mechanisms in the control of signal transduction, cell proliferation, differentiation, and neoplastic transformation [1–4]. The net cellular level of tyrosine phosphorylation is maintained dynamically by the opposing actions of protein tyrosine kinases (PTKs) and ...
Yi-Fan Zhai +3 more
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Protein tyrosine phosphorylation and dephosphorylation are believed to be key regulatory mechanisms in the control of signal transduction, cell proliferation, differentiation, and neoplastic transformation [1–4]. The net cellular level of tyrosine phosphorylation is maintained dynamically by the opposing actions of protein tyrosine kinases (PTKs) and ...
Yi-Fan Zhai +3 more
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Protein tyrosine phosphatases take off
Nature Structural & Molecular Biology, 1995Protein tyrosine phosphatases (PTPs) are a family of signal transduction enzymes that dephosphorylate phosphotyrosine containing proteins. Structural and kinetic studies provide a molecular understanding of how these enzymes regulate a wide range of intracellular processes.
D, Barford, Z, Jia, N K, Tonks
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Protein Tyrosine Phosphatases in Osteoclasts
Critical Reviews™ in Eukaryotic Gene Expression, 2007Osteoclasts are large cells derived from the monocyte-macrophage hematopoietic cell lineage, whose primary function is to degrade bone in various physiological contexts. Reversible phosphorylation of tyrosine residues in proteins is known to play significant roles in regulating the function of osteoclasts, much as it does in other cell types.
Shira, Granot-Attas +2 more
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Receptor Protein-Tyrosine Phosphatase Dimerization
2003Publisher Summary This chapter discusses that the receptor protein-tyrosine phosphatases (RPTPs) form a subfamily of the classical protein-tyrosine phosphatase family. It is established that the enzymatic counterparts of the RPTPs, the receptor protein-tyrosine kinases (RPTKs), are regulated by ligand binding to their extracellular domain, for ...
Jeroen, den Hertog +3 more
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2000
The importance of tyrosine phosphorylation in diverse cellular processes such as cell growth, gene expression, metabolism, differentiation, cytoskeletal dynamics, and cell motility was discovered primarily through studies of the protein tyrosine kinases (PTKs).
Cynthia V. Stauffacher +1 more
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The importance of tyrosine phosphorylation in diverse cellular processes such as cell growth, gene expression, metabolism, differentiation, cytoskeletal dynamics, and cell motility was discovered primarily through studies of the protein tyrosine kinases (PTKs).
Cynthia V. Stauffacher +1 more
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Assays for Protein-Tyrosine Phosphatases
2002Many studies have implicated protein-tyrosine phosphatases (PTPases) as important regulators of cellular functions and as potential drug targets. This has led to an increased interest in the development of precise assays for detailed mechanistic studies of PTPases, rapid assays for high-throughput PTPase inhibitor screening, and more biologically ...
Daniel F, McCain, Zhong-Yin, Zhang
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