Results 261 to 270 of about 79,142 (299)
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1998
Abstract The first descriptions of PTPases in cell and tissue extracts provided evidence that they were distinct from other protein phosphatases because of their substrate specificity, neutral pH optimum, resistance to EDT A, and unique inhibition by low concentrations of zinc or vanadate [33].
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Abstract The first descriptions of PTPases in cell and tissue extracts provided evidence that they were distinct from other protein phosphatases because of their substrate specificity, neutral pH optimum, resistance to EDT A, and unique inhibition by low concentrations of zinc or vanadate [33].
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Protein tyrosine phosphatases in signaling
Current Opinion in Cell Biology, 1996During the past few years, molecular cloning has established the existence of a structurally diverse family of intracellular and transmembrane protein tyrosine phosphatases (PTPases). The importance of PTPases in signaling is best understood in three model systems: the mammalian transmembrane CD45 PTPase, the Drosophila Src homology (SH)2 domain ...
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Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
Nature Reviews Drug Discovery, 2023Nunzio Bottini
exaly
Receptor protein tyrosine phosphatases
2003The receptor protein-tyrosine phosphatases (RPTPs) form a subfamily of the classical protein-tyrosine phosphatases (PTPs). RPTPs are interesting because they have the ability to signal across the cell membrane due to their topology. Evidence is accumulating that RPTPs play important roles during embryonic development and in human disease.
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Kinases/Phosphatases | Protein Tyrosine Phosphatases
2013D.J. Pagliarini +3 more
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Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses
Nature Reviews Drug Discovery, 2007Kate L Jeffrey, Montserrat Camps
exaly