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© 2013 Elsevier Inc. All rights reserved. Serine proteinases signal to cells by cleaving and activating a four-member family of seven-transmembrane G-protein-coupled receptors (GPCRs) termed, proteinase-activated receptors (PARs). PARs are unique among GPCRs in having a mechanism of activation that involves the proteolytic cleavage and unmasking of a ...
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