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Proteinase-activated receptors (PARs)
2008Proteinase-activated receptors (PARs) are a unique family of G-protein-coupled receptors (GPCRs) that are activated in response to serine proteinases. There are four PAR family members; PAR-1 through to PAR-4. PAR-1 and PAR-3 respond to thrombin, PAR-2 responds to trypsin, whilst PAR-4 is sensitive to both thrombin- and trypsin-related proteinases.
Cunningham, Margaret Rose, Plevin, Robin
openaire +2 more sources
[Proteinase-activated receptor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2007Maho, Matsunami +2 more
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Targeting proteinase-activated receptors: therapeutic potential and challenges
Nature Reviews Drug Discovery, 2012Rithwik Ramachandran +2 more
exaly
Proteinase-activated receptors and nociceptive pathways
Drug Development Research, 2003Nathalie Vergnolle
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