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Proteinase-Activated Receptors
Pharmacological Reviews, 2001Proteinase-activated receptors are a recently described, novel family of seven-transmembrane G-protein-coupled receptors. Rather then being stimulated through ligand receptor occupancy, activation is initiated by cleavage of the N terminus of the receptor by a serine protease resulting in the generation of a new tethered ligand that interacts with the ...
S R, Macfarlane +4 more
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Gastrointestinal functions of proteinase-activated receptors
Life Sciences, 2003Proteinase-activated receptors (PARs) are a family of G-protein-coupled-seven-trans-membrane-domain receptors, consisting of four family members. PARs, especially PAR-1, a thrombin receptor, and PAR-2, a receptor for trypsin, tryptase and coagulation factors VIIa and Xa, are abundantly distributed throughout the gastrointestinal tract.
Atsufumi Kawabata
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Proteinase-activated receptors in the nervous system
Nature Reviews Neuroscience, 2003Recent data point to important roles for proteinases and their cognate proteinase-activated receptors (PARs) in the ontogeny and pathophysiology of the nervous system. PARs are a family of G-protein-coupled receptors that can affect neural cell proliferation, morphology and physiology.
Farshid, Noorbakhsh +3 more
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Proteinase-activated receptors in ovine cervical function
Reproduction, Fertility and Development, 2005In sheep, inflammation not only functions in cervical dilation at parturition, but also plays an important part in the non-pregnant ewe cervix, as demonstrated by the high level of expression of interleukin (IL)-8 at oestrus. Ewes artificially induced to ovulate have significantly lower levels of IL-8 gene expression at oestrus compared with natural ...
Mitchell, SE +3 more
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The therapeutic potential of proteinase-activated receptors in arthritis
Current Opinion in Pharmacology, 2007Proteinase-activated receptors are a family of seven-transmembrane G-protein-coupled receptors. Activation of PARs is initiated through cleavage of the N-terminus, unmasking a tethered ligand that can then interact with the receptor and lead to its activation. PARs exhibit both anti- and pro-inflammatory properties, although recent evidence has pointed
McIntosh, Kathryn A +3 more
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