Results 291 to 300 of about 409,825 (329)

Membrane Vesicles from Lacticaseibacillus Casei BL23 Exhibit Antimicrobial Activity Against Escherichia coli and Immunostimulatory Effects on Human Peripheral Blood Mononuclear Cells

Advanced Healthcare Materials, EarlyView.
Membrane vesicles derived from the probiotic Lacticaseibacillus casei BL23 demonstrate antimicrobial properties against Escherichia coli and a potential biological effect in improving the overall survival of C. elegans infected with Pseudomonas aeruginosa. These vesicles stimulated immune responses in primary cells without causing toxicity. Our results
Cecilia L. D'Antoni, Leila Pourtalebi Jahromi, Lorenzo Sana, Ana Paula Domínguez Rubio, Maja Dorfner, Jennifer Munkert, Heike Danzer, Philipp Arnold, Mikhail Lebedev, Esther Zanin, Oscar E. Pérez, Gregor Fuhrmann   +11 more
wiley   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source

Structure, Biochemistry and Comparative Aspects of Mammalian Seminal Plasma Acrosin Inhibitors [PDF]

, 1976
Fink, Edwin, Fritz, Hans, Klauser, R., Kupfer, S., Peeters, H., Tschesche, Harald   +5 more
core  

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Pathomechanismus in Septic Shock [PDF]

, 1986
Duswald, Karl-Heimo, Eitel, F., Fritz, Hans, Inthorn, D., Jochum, Marianne, Schweiberer, L.   +5 more
core  

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Proteinase 3 phosphonic inhibitors

Biochimie, 2019
Neutrophils are one of the most important military services of the armed forces of the immune system, a crucial line of defense against bacterial or fungal onslaughts. One of their mechanisms of action relies on the production of serine proteases.
Renata Grzywa, Adam Lesner, Brice Korkmaz, Marcin Sieńczyk   +3 more
openaire   +3 more sources

Inhibitors of human leukocyte proteinase-3

Journal of Medicinal Chemistry, 1990
Full text of this article is not available in SOAR.
Groutas, William C., Hoidal, John R., Brubaker, Michael J., Stanga, Michael A., Venkataraman, Radhika, Gray, B. H., Rao, Narayanam V.   +6 more
openaire   +2 more sources

Immune Functions of Proteinase 3

Critical Reviews in Immunology, 2005
The primary function of neutrophil-derived serine proteases, neutrophil elastase, cathepsin G, and proteinase 3 (PR3) are thought to be the degradation of extracellular proteins at sites of inflammation, but excessive, prolonged, or inappropriate proteolytic activity causes harmful effects in the body.
openaire   +2 more sources

Proteinase 3. A neutrophil proteinase with activity on platelets.

The Journal of Immunology, 1994
Abstract Purified proteinase 3 (PR3) devoid of any elastase (HLE) and cathepsin G (Cat.G) contaminants, was prepared from azurophilic granules of human polymorphonuclear neutrophils by using a novel procedure. Although unable to induce platelet activation (up to 25 micrograms/ml) by itself, PR3 at a concentration as low as 2.5 micrograms/
P, Renesto, L, Halbwachs-Mecarelli, P, Nusbaum, P, Lesavre, M, Chignard   +4 more
openaire   +2 more sources

Membrane proteinase 3 and Wegener’s granulomatosis

Clinical Nephrology, 2005
Proteinase 3 (PR3) is found in neutrophil and monocyte lysosomal granules. Anti-neutrophil cytoplasmatic antibodies (ANCA) with specificity for PR3 are characteristic for patients with Wegener's granulomatosis. The interaction of ANCA with neutrophilic ANCA antigens is necessary for the development of ANCA-associated diseases.
S, von Vietinghoff, A, Schreiber, B, Otto, M, Choi, U, Göbel, R, Kettritz   +5 more
openaire   +2 more sources