Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2000 Hematopoiesis depends on a pool of quiescent hematopoietic stem/progenitor cells. When exposed to specific cytokines, a portion of these cells enters the cell cycle to generate an amplified progeny. Myeloblastin (MBN) initially was described as involved in proliferation of human leukemia cells.
Pierre G Lutz, Christel Moog-Lutz
exaly +5 more sources
Proteases and Protease Inhibitors of Urinary Extracellular Vesicles in Diabetic Nephropathy [PDF]
Journal of Diabetes Research, 2015 Diabetic nephropathy (DN) is one of the major complications of diabetes mellitus (DM), leads to chronic kidney disease (CKD), and, ultimately, is the main cause for end-stage kidney disease (ESKD).
Luca Musante +6 more
doaj +6 more sources
Proteolytic Degradation Is a Major Contributor to Bioprosthetic Heart Valve Failure [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023 Background Whereas the risk factors for structural valve degeneration (SVD) of glutaraldehyde‐treated bioprosthetic heart valves (BHVs) are well studied, those responsible for the failure of BHVs fixed with alternative next‐generation chemicals remain ...
Alexander E. Kostyunin +16 more
doaj +2 more sources
Wegener autoantigen and myeloblastin are encoded by a single mRNA. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1991 Myeloblastin is a serine protease that has been identified in the human leukemia cell line HL-60. Down-regulation of this protease can inhibit proliferation and induce differentiation of promyelocyte-like human leukemic cells. Proteinase 3, a serine protease of human neutrophils, has been identified as the Wegener autoantigen.
C, Labbaye, P, Musette, Y E, Cayre
exaly +3 more sources
pH-dependent hysteretic behaviour of human myeloblastin (leucocyte proteinase 3) [PDF]
Biochemical Journal, 1996 Human myeloblastin (leucocyte proteinase 3) showed a very slow approach to the steady-state velocity when the pH was rapidly increased from 3.2 to 7.0. The kinetic mechanism of this hysteretic process was interpreted as a slow conformational change of myeloblastin from an inactive form at acidic pH to the active form at neutral pH.
Antonio Baici +2 more
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Cell, 1989 Cells from the human leukemia cell line HL-60 undergo terminal differentiation when exposed to inducing agents. Differentiation of these cells is always accompanied by withdrawal from the cell cycle. Here we describe the isolation of a cDNA encoding a novel serine protease that is present in HL-60 cells and is down-regulated during induced ...
Zbigniew Darzynkiewicz
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Regulation of myeloblastin messenger RNA expression in myeloid leukemia cells treated with all-trans retinoic acid [PDF]
Blood, 1993 Abstract Retinoic acid is known to induce differentiation of human myeloid leukemia cells in vitro. Recently, all-trans retinoic acid has been used to induce remissions in patients with acute promyelocytic leukemia, probably through differentiation of the leukemia cells.
M Lanotte, Wh Miller
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MCF‐7 mammary tumour cells express the myeloid cell differentiation controlling factor, serine protease3/myeloblastin [PDF]
Cell Proliferation, 2000 Our previous data indicated that HSP27 plays a role in MCF‐7 cell differentiation similar to that it has in HL‐60 cells. In the latter case, this involves a control of its levels by proteinase 3/myeloblastin (PR3/Mbn), a serine proteinase hitherto considered specific of the myeloid lineage.
P Galand
exaly +4 more sources
Identity of Wegener's autoantigen (p29) with proteinase 3 and myeloblastin [letter] [PDF]
Blood, 1990 Ma Arnaout
exaly +3 more sources
Effect of food intake on 92 biomarkers for cardiovascular disease. [PDF]
PLoS ONE, 2017 OBJECTIVE:The present study evaluates the effect of food intake on 92 biomarkers for cardiovascular disease (CVD). METHODS:Twenty two healthy subjects (11 male and 11 female aged 25.9±4.2 years) were investigated.
Magnus Dencker +3 more
doaj +1 more source