Results 41 to 50 of about 1,083 (144)

Characterization of Cystatin B Interactome in Saliva from Healthy Elderly and Alzheimer's Disease Patients [PDF]

, 2023
Cystatin B is a small, multifunctional protein involved in the regulation of inflammation, innate immune response, and neuronal protection and found highly abundant in the brains of patients with Alzheimer's disease (AD). Recently, our study demonstrated
Bizzarro, Alessandra, Cabras, Tiziana, Castagnola, Massimo, Contini, Cristina, Guadalupi, Giulia, Iavarone, Federica, Maccarrone, Giuseppina, Manconi, Barbara, Masullo, Carlo, Messana, Irene, Olianas, Alessandra, Serrao, Simone, Turck, Christoph W   +12 more
core   +1 more source

Clinical proteomic biomarkers: relevant issues on study design & technical considerations in biomarker development

Clinical and Translational Medicine, Volume 3, Issue 1, December 2014., 2014
Abstract Biomarker research is continuously expanding in the field of clinical proteomics. A combination of different proteomic–based methodologies can be applied depending on the specific clinical context of use. Moreover, current advancements in proteomic analytical platforms are leading to an expansion of biomarker candidates that can be identified.
Maria Frantzi, Akshay Bhat, Agnieszka Latosinska   +2 more
wiley   +1 more source

A despecialization step underlying evolution of a family of serine proteases

, 2003
In the trypsin superfamily of serine proteases, non-trypsin-like primary specificities have arisen in only two monophyletic descendent subbranches. We have recreated an ancestor to one of these subbranches (granzyme) using phylogenetic inference, gene ...
Birktoft, Bone, Caputo, Chandrasekharan, Chang, Graf, Hajnik, Hedstrom, Heusel, Hof, Hung, Jermann, Killian, Kraulis, Kumar, Malcolm, McGrath, Merritt, Pauling, Perona, Pletnev, Poe, Poorafshar, Powers, Rehault, Remington, Sanker, Shotton, Smyth, Solivan, Sreenivasan, Stackhouse, Strimmer, Thompson, Tsu, Venekei, Waugh, Wyss   +37 more
core   +1 more source

Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics

The Scientific World Journal, Volume 2014, Issue 1, 2014., 2014
Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment
Petra Hudler, Nina Kocevar, Radovan Komel, P. Cassoni, L. Messerini   +4 more
wiley   +1 more source

Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression. [PDF]

, 2020
Current knowledge on the biology of squamous cell vulvar carcinoma (VSCC) is limited. We aimed to identify protein markers of VSCC tumors that would permit to stratify patients by progression risk.
Bakuła-Zalewska, Elwira, Domański, Dominik, Fatalska, Agnieszka, Goryca, Krzysztof, Kowalewska, Magdalena, Kowalik, Artur, Rusetska, Natalia, Wroblewska, Agnieszka, Zalewski, Kamil, Zięba, Sebastian   +9 more
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Salivary Proteomic Signatures in Pregnant Women With Excessive Gingival Bleeding

Oral Diseases, Volume 32, Issue 3, Page 852-863, March 2026.
ABSTRACT Objective This observational, cross‐sectional, and analytical study aimed to explore the pathophysiological mechanisms of gingivitis in pregnancy by analyzing the salivary proteomic profile according to gingival bleeding status. Materials and Methods Pregnant women at the 27th week of gestation or beyond were categorized into two groups: those
Gerson Aparecido Foratori‐Junior, Clovis Bergamin Griso, Amanda Borges Pirondi, Laura Teodoro de Marchi, Talita Mendes Oliveira Ventura, Larissa Tercilia Grizzo, Roosevelt da Silva Bastos, Alejandra Chaparro, Nagihan Bostanci, Marília Afonso Rabelo Buzalaf   +9 more
wiley   +1 more source

Neutrophil‐derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation

Mediators of Inflammation, Volume 3, Issue 4, Page 257-273, 1994., 1994
Neutrophils generate potent microbicidal molecules via the oxygen‐dependent pathway, leading to the generation of reactive oxygen intermediates (ROI), and via the non‐oxygen dependent pathway, consisting in the release of serine proteinases and metalloproteinases stored in granules.
V. Witko-Sarsat, B. Descamps-Latscha
wiley   +1 more source

The model of proteolysis [PDF]

, 2010
This document presents the original approach for estimating parameters of proteolysis process. Data used to fit the model are taken from mass spectrometric experiments. For parameters estimation the Levenberg-Marquadt algorithm is used.
Anna Gambin, Piotr Dittwald
core   +1 more source

Clonogenicity, gene expression and phenotype during neutrophil versus erythroid differentiation of cytokine-stimulated CD34 human marrow cells in vitro. [PDF]

, 2004
With the objective to correlate clonogenicity, gene expression and phenotype during differentiation, human bone marrow CD34+ cells were cultured in vitro to stimulate erythroid or neutrophil development, and sorted into five subpopulations according to ...
Dykes, Josefina, Edvardsson, Louise, Olofsson, Tor, Olsson, Martin L   +3 more
core   +2 more sources

Lipids and emerging cardiovascular- and inflammation-related proteins in early, treatment-naïve rheumatoid arthritis [PDF]

, 2023
Kardiovaskulær sygdom (CVD) og -mortalitet er 1,5-2 gange hyppigere forekommende hos patienter med reumatoid artritis (RA) end hos baggrundsbefolkningen.
Masic, Dzenan
core   +1 more source