Respiratory Research, 2018 Chronic Obstructive Pulmonary Disease (COPD) is a common, multifactorial lung disease which results in significant impairment of patients’ health and a large impact on society and health care burden.
Helena Crisford +2 more
doaj +1 more source
Cytosine demethylation of the proteinase-3/myeloblastin primary granule protease gene during phagocyte development [PDF]
Leukemia, 1999 Proteinase-3/Myeloblastin (Mbn) is a neutral serine protease and a major constituent of the primary granules of myeloid cells. It can degrade extracellular matrix proteins and has been discussed as a key factor for the initiation of terminal differentiation in promyelocytic cells.
Lübbert, Michael +2 more
openaire +3 more sources
Exosomes in Nephropathies: A Rich Source of Novel Biomarkers
Disease Markers, Volume 2020, Issue 1, 2020., 2020 The biomarkers commonly utilized in diagnostic evaluations of kidney disease suffer from low sensitivity, especially in the early stages of renal damage. On the other hand, obtaining a renal biopsy to augment clinical decision making can lead to potentially serious complications.
Christos Masaoutis +4 more
wiley +1 more source
Genome-wide DNA methylation assay reveals novel candidate biomarker genes in cervical cancer [PDF]
, 2013 The oncogenic human papilloma viruses (HPVs) are associated with precancerous cervical lesions and development of cervical cancer. The DNA methylation signatures of host genome in normal, precancerous and cervical cancer tissue may indicate tissue ...
Farkas, Sanja A. +3 more
core +1 more source
Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: A hypothesis [PDF]
, 2012 Despite extensive understanding of sleep regulation, the molecular-level cause and function of sleep are unknown. I suggest that they originate in individual neurons and stem from increased production of protein fragments during wakefulness.
Varshavsky, Alexander
core +1 more source
Acquired enamel pellicle protects gastroesophageal reflux disease patients against erosive tooth wear [PDF]
, 2023 The objective of this study was to compare the protein profile of the acquired enamel pellicle (AEP) formed in vivo in patients with or without gastroesophageal reflux disease (GERD), and with or without erosive tooth wear (ETW).
Adrian LUSSI +15 more
core +2 more sources
Waist-to-hip ratio and mortality in heart failure [PDF]
, 2018 Aims: A higher body mass index (BMI) is associated with better survival in heart failure (HF) patients, also known as the obesity paradox. However, BMI does not account for body composition.
Assarsson +36 more
core +3 more sources
Plasma Protein Profiling Analysis in Patients with Atrial Fibrillation Before and After Three Different Ablation Techniques [PDF]
, 2023 Background: There are controversies on the pathophysiological alteration in patients with atrial fibrillation (AF) undergoing pulmonary vein isolation using different energy sources.
Bao, Yangyang +22 more
core +2 more sources
Comparing biomarker profiles of patients with heart failure:atrial fibrillation vs. sinus rhythm and reduced vs. preserved ejection fraction [PDF]
, 2018 Aims: The clinical correlates and consequences of atrial fibrillation (AF) might be different between heart failure with reduced vs. preserved ejection fraction (HFrEF vs. HFpEF).
Anker, Stefan D. +23 more
core +4 more sources
Novel Insights Into the Effects of Interleukin 6 Antagonism in Non-ST-Segment-Elevation Myocardial Infarction Employing the SOMAscan Proteomics Platform [PDF]
, 2020 Background: Interleukin 6 concentration is associated with myocardial injury, heart failure, and mortality after myocardial infarction. In the Norwegian tocilizumab non-ST-segment-elevation myocardial infarction trial, the first randomized trial of ...
Aukrust, Pål +12 more
core +2 more sources