Results 301 to 310 of about 409,825 (329)

Selective Inhibitors of Human Neutrophil Proteinase 3

Current Pharmaceutical Design, 2012
Human neutrophil proteinase 3 (PR3) and elastase (HNE) are homologous serine proteinases involved in the proteolytic events associated with inflammation and infection. Their close structural and functional resemblance makes it difficult to understand their respective biological functions.
Brice, Korkmaz, Christine, Kellenberger, Marie-Claude, Viaud-Massuard, Francis, Gauthier   +3 more
openaire   +2 more sources

Induction of proteinase 3-anti-neutrophil cytoplasmic autoantibodies by proteinase 3-homologous bacterial protease in mice

Immunologic Research, 2015
Proteinase 3 (PR3) is the principal target of antineutrophil cytoplasmic autoantibodies (ANCA) associated with granulomatosis with polyangiitis. The aim of this study was to investigate whether bacterial PR3-homologous protease can induce autoantibodies to PR3 and ANCA-associated pathology in mice.
Yong Chul Kim, Yun Sik Choi, Jehan Alam, Yun-ji Kim, Keum Jin Baek, Jaemoon Koh, Yeong Wook Song, Doo-Hyun Chung, Youngnim Choi   +8 more
openaire   +2 more sources

ANCA antigens: Proteinase 3

1994
The antigen for the cANCA reactivity is the serine protease Proteinase 3 (PR-3). In 1988 several groups showed that the antigen was a protein with a molecular weight of 29 kDa [1–3] and in 1989 three groups showed by N-terminal sequencing that the antigen was PR-3 [4–6].
Jörgen Wieslander, Allan Wiik
openaire   +1 more source

Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis

American Journal of Kidney Diseases, 1995
The serine proteinases proteinase 3 (PR3) and elastase are target antigens of antineutrophil cytoplasmic autoantibodies (ANCAs), which are found in various systemic vasculitides with rapidly progressive glomerulonephritis (RPGN). The expression of both proteinases was studied immunohistologically (avidin-biotin complex method) with murine monoclonal ...
C, Mrowka, E, Csernok, W L, Gross, H E, Feucht, U, Bechtel, G H, Thoenes   +5 more
openaire   +2 more sources

Generation of Anti-Proteinase 3 Monoclonal Antibodies and Development of Immunological Methods to Detect Endogenous Proteinase 3

Hybridoma, 2010
Proteinase 3 (PR3), a neutrophil granule serine protease, is the major autoantigen for autoantibodies in the systemic vasculitic disease, Wegener's granulomatosis. It is also found to be involved in various inflammatory diseases including Crohn's disease, rheumatoid arthritis, cystic fibrosis, and gingivitis.
Suyoung, Bae, Jida, Choi, Jaewoo, Hong, Siyoung, Lee, Erk, Her, Wonhyuk, Choi, Sangmin, Kim, Youngbum, Choi, Soohyun, Kim   +8 more
openaire   +2 more sources

Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs

Insect Biochemistry and Molecular Biology, 2003
Phenoloxidase (PO) is a key enzyme implicated in several defense mechanisms in insects and crustaceans. It is converted from prophenoloxidase (proPO) through limited proteolysis by prophenoloxidase-activating proteinase (PAP). We previously isolated PAP-1 from integument and PAP-2 from hemolymph of the tobacco hornworm, Manduca sexta.
Haobo, Jiang, Yang, Wang, Xiao-Qiang, Yu, Yifei, Zhu, Michael, Kanost   +4 more
openaire   +2 more sources

Proteinase 3, Wegener's autoantigen

Journal of Leukocyte Biology, 2001
Proteinase 3 (PR3) is one of four serine protease homologues in the azurophilic granules of neutrophils and granules of monocytes, It is of importance that anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosis (WG) are mainly directed against PR3 only, Furthermore, PR3 is overexpressed in a variety of acute and chronic
van der Geld, YM, Limburg, PC, Kallenberg, CGM   +2 more
openaire   +1 more source

Elafin is a potent inhibitor of proteinase 3

Biochemical and Biophysical Research Communications, 1991
Elafin, a human skin derived inhibitor of human leukocyte elastase, was tested for inhibitory activity against proteinase 3, an elastin degrading proteinase of neutrophils. The inhibitory activity of elafin was compared with antileukoprotease and eglin C. Elafin proved to be a potent inhibitor of elastin-FITC degradation showing an IC 50 of 9.5 x 10(-9)
O, Wiedow, J, Lüademann, B, Utecht
openaire   +2 more sources

How does Proteinase 3 interact with lipid bilayers?

Physical Chemistry Chemical Physics, 2010
Proteinase 3 (PR3) is a serine protease of the neutrophils whose membrane expression is relevant in a number of inflammatory pathologies. It has been shown to strongly interact with reconstituted bilayers containing dimyristoylphosphatidylcholine (DMPC), dimyristoylphosphatidylglycerol (DMPG) or mixtures of both phospholipids.
Torben, Broemstrup, Nathalie, Reuter
openaire   +2 more sources

Proteinase 3, Wegener's autoantigen: from gene to antigen

Journal of Leukocyte Biology, 2001
AbstractProteinase 3 (PR3) is one of four serine protease homologues in the azurophilic granules of neutrophils and granules of monocytes. It is of importance that anti-neutrophil cytoplasmic antibodies (ANCA) in patients with Wegener's granulomatosis (WG) are mainly directed against PR3 only. Furthermore, PR3 is overexpressed in a variety of acute and
Y M, van der Geld, P C, Limburg, C G, Kallenberg   +2 more
openaire   +2 more sources