Results 301 to 310 of about 357,202 (334)

Inhalability and Bioactivity of Spray‐Dried versus Pressurized Gas eXpanded Liquid Technology‐Processed Yeast Beta‐Glucan Microparticles for Anti‐Fibrotic Therapies

Advanced Healthcare Materials, EarlyView.
PGXTEC) liquid technology is utilized to develop highly respirable yeast beta‐glucan (YBG) microparticles for the treatment of pulmonary fibrosis. Compared to conventionally processed spray‐dried YBG, PGXTEC‐YBG exhibits greatly improved aerodynamic properties, enhanced pro‐fibrotic macrophage uptake, and effective downregulation of pro‐fibrotic ...
Nate Dowdall, Safaa Naiel, Quan Zhou, Pareesa Ali, Tamana Rubina Yousof, Emily Wong, Ricardo Couto, Byron Yépez, Bernhard Seifried, Paul Moquin, Rod Rhem, Myrna Dolovich, Martin Rainer Kolb, Kjetil Ask, Todd Hoare   +14 more
wiley   +1 more source

Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun, Elizabeth S. Nakasone, Ha Eun Shin, Hyojin Lee, Jong‐Chan Park, Wonhwa Lee, Wooram Park, Chun Gwon Park, Juwon Park, Se‐Na Kim   +9 more
wiley   +1 more source

Printing and Rerouting of Elastic and Protease Responsive Shape Memory Hydrogel Filaments

Advanced Healthcare Materials, EarlyView.
A biofabrication strategy, Rerouting of Free‐Floating Suspended Hydrogel Filaments (REFRESH), is developed enabling the printing of highly elastic, reconfigurable protease‐responsive hydrogel filaments with shape memory properties. The filaments can be manually braided, knotted, and rerouted to create intricate cell‐laden 3D architectures, expanding ...
Philip Lifwergren, Viktoria Schoen, Sajjad Naeimipour, Lalit Khare, Anna Wunder, Hanna Blom, Jose G. Martinez, Pierfrancesco Pagella, Anders Fridberger, Johan Junker, Daniel Aili   +10 more
wiley   +1 more source

Mechanical Reinforced and Self‐healing Hydrogels: Bioprinted Biomimetic Methacrylated Collagen Peptide‐Xanthan Gum Constructs for Ligament Regeneration

Advanced Healthcare Materials, EarlyView.
Readily UV‐curing and self‐healing methacrylated collagen peptide (COPMA) hydrogels are developed with tunable mechanical properties. As the interpenetrating network between COPMA and xanthan gum (XG), COPMA‐XG bioinks show improved mechanical properties, printability, and stability, compared to COPMA or XG.
Hongjuan Weng, Monize Caiado Decarli, Lei He, Wen Chen, Sabine van Rijt, Katrien V. Bernaerts, Lorenzo Moroni   +6 more
wiley   +1 more source

Pathomechanismus in Septic Shock [PDF]

, 1986
Duswald, Karl-Heimo, Eitel, F., Fritz, Hans, Inthorn, D., Jochum, Marianne, Schweiberer, L.   +5 more
core  

Inhibitors of human leukocyte proteinase-3 [PDF]

Journal of Medicinal Chemistry, 1990
Full text of this article is not available in SOAR.
Groutas, William C., Hoidal, John R., Brubaker, Michael J., Stanga, Michael A., Venkataraman, Radhika, Gray, B. H., Rao, Narayanam V.   +6 more
openaire   +2 more sources

Kinetics of the Inhibition of Proteinase 3 by Elafin [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2001
Excessive proteolytic activity of proteinase 3 (Pr3) has been suggested to be a factor contributing to the pathogenesis of emphysema and other inflammatory disorders. We report here on the kinetics of inhibition of Pr3 by one of its major endogenous inhibitors, the 6-kD inhibitory domain of elafin.
Sanford R. Simon, Qi-Long Ying
openaire   +2 more sources

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Proteinase 3. A neutrophil proteinase with activity on platelets.

The Journal of Immunology, 1994
Abstract Purified proteinase 3 (PR3) devoid of any elastase (HLE) and cathepsin G (Cat.G) contaminants, was prepared from azurophilic granules of human polymorphonuclear neutrophils by using a novel procedure. Although unable to induce platelet activation (up to 25 micrograms/ml) by itself, PR3 at a concentration as low as 2.5 micrograms/
P, Renesto, L, Halbwachs-Mecarelli, P, Nusbaum, P, Lesavre, M, Chignard   +4 more
openaire   +2 more sources

Proteinase 3 phosphonic inhibitors

Biochimie, 2019
Neutrophils are one of the most important military services of the armed forces of the immune system, a crucial line of defense against bacterial or fungal onslaughts. One of their mechanisms of action relies on the production of serine proteases.
Renata Grzywa, Adam Lesner, Brice Korkmaz, Marcin Sieńczyk   +3 more
openaire   +3 more sources

[3] Myeloblastin: Leukocyte proteinase 3

1994
Publisher Summary This chapter describes assay, purification, and properties of myeloblastin. Myeloblastin is a neutral serine endopeptidase produced during myeloid differentiation and stored in the azurophilic granules of polymorphonuclear leukocytes (PMNs).
John R. Hoidal, Beulah H. Gray, Narayanam V. Rao   +2 more
openaire   +3 more sources